Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis.
Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis.
复制标题
DOI：
10.3390/nu10040409
复制
发表时间：
2018-03-26
期刊：
影响因子：
5.9
通讯作者：
Lin CY
中科院分区：
文献类型：
--
作者：
Lee MD;Lin CH;Lei WT;Chang HY;Lee HC;Yeung CY;Chiu NC;Chi H;Liu JM;Hsu RJ;Cheng YJ;Yeh TL;Lin CY
流感病毒感染是一个重大的全球公共卫生问题，流感疫苗接种的效果并不令人满意。维生素D参与许多免疫介导的炎症过程。维生素D水平对流感疫苗免疫原性反应的影响尚不清楚。我们对维生素D和流感疫苗接种的研究进行了全面的文献检索和系统回顾。分析了与研究人群、疫苗组分、维生素D水平和免疫原性反应有关的数据。9项研究（合并研究人群2367例患者）被纳入系统性综述。在荟萃分析中纳入了4项研究，以调查维生素D缺乏（VDD）对流感疫苗接种后血清保护（SP）率和血清转换（SC）率的影响。我们发现维生素D水平和流感疫苗免疫原性反应之间没有显着关联。然而，可能存在菌株特异性差异。我们观察到VDD患者中甲型流感病毒亚型H3 N2（A/H3 N2）和B株的SP率低于维生素D水平正常的患者（A/H3 N2：71.8% vs. 80.1%，比值比（OR）：0.63，95%置信区间（CI）：0.43-0.91，p = 0.01; B毒株：69.6% vs. 76.4%，OR：0.68，95% CI：0.5-0.93，p = 0.01）。VDD组和对照组的甲型H1N1流感病毒SP率和SC率均无显著性差异。总之，未观察到VDD与流感疫苗接种的免疫原性反应之间存在关联。
Influenza virus infection is a major global public health problem, and the efficacy of influenza vaccination is not satisfactory. Vitamin D is involved in many immune-mediated inflammatory processes. The impact of vitamin D levels on the immunogenic response to influenza vaccination is not clear. We performed a comprehensive literature search and systematic review of studies that investigated vitamin D and influenza vaccination. Data pertaining to study population, vaccine components, vitamin D levels, and immunogenic response were analyzed. Nine studies, with a combined study population of 2367 patients, were included in the systematic review. Four studies were included in the meta-analysis to investigate the influence of vitamin D deficiency (VDD) on the seroprotection (SP) rates and seroconversion (SC) rates following influenza vaccination. We found no significant association between vitamin D level and the immunogenic response to influenza vaccination. However, strain-specific differences may exist. We observed lower SP rates of influenza A virus subtype H3N2 (A/H3N2) and B strain in VDD patients than patients with normal vitamin D levels (A/H3N2: 71.8% vs. 80.1%, odds ratio (OR): 0.63, 95% confidence interval (CI): 0.43–0.91, p = 0.01; B strain: 69.6% vs. 76.4%, OR: 0.68, 95% CI: 0.5–0.93, p = 0.01). However, the SP rates of A/H1N1 and SC rates of all three strains were not significantly different in VDD and control groups. In conclusion, no association was observed between VDD and immunogenic response to influenza vaccination.
登录
查看更多内容
影响因子：
5.8
作者：
Holick, Michael F.;Binkley, Neil C.;Weaver, Connie M.
通讯作者：
Weaver, Connie M.
影响因子：
4.5
作者：
Forrest, Kimberly Y. Z.;Stuhldreher, Wendy L.
通讯作者：
Stuhldreher, Wendy L.
影响因子：
--
作者：
Cooper, Curtis;Thorne, Anona
通讯作者：
Thorne, Anona
影响因子：
2.8
作者：
Chadha, Manpreet K.;Fakih, Marwan;Trump, Donald
通讯作者：
Trump, Donald
影响因子：
2
作者：
Higgins, JPT;Thompson, SG
通讯作者：
Thompson, SG