A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery.
A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery.
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用于肿瘤酸性边缘描绘和图像引导手术的 pH 比率响应表面增强共振拉曼散射探针
DOI：
10.1039/d0sc00844c
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发表时间：
2020-04-07
期刊：
影响因子：
8.4
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Duan W;Yue Q;Liu Y;Zhang Y;Guo Q;Wang C;Yin S;Fan D;Xu W;Zhuang J;Gong J;Li X;Huang R;Chen L;Aime S;Wang Z;Feng J;Mao Y;Zhang XY;Li C
手术仍然是大多数实体瘤治疗的主要手段。然而，外科医生面临的挑战，在术中识别浸润性肿瘤边缘，由于其浸润性的性质。不完全切除通常导致早期复发，而积极的切除可能会损伤邻近的功能组织。在此，我们报告了一种pH响应的比率表面增强拉曼散射（SERRS）探针，通过一种创新的机制，空间取向诱导的分子内能量转移（SOIET），确定生理pH值与高灵敏度和组织渗透深度。由于肿瘤酸度与恶性程度之间的正相关性，通过术中评估肿瘤切缘中可疑组织的组织pH/恶性程度，在活体动物模型中实施酸性边缘引导的手术策略。该手术显著延长了动物模型的生存期，并最大限度地减少了术后并发症，显示出精确识别侵袭性肿瘤边界并实现最大肿瘤减积和最小功能损害之间平衡的前景。研制了一种新型的pH比值响应表面增强共振拉曼散射（SERRS）探针，用于肿瘤酸性边缘勾画和图像引导手术。
Surgery remains the mainstay for most solid tumor treatments. However, surgeons face challenges in intra-operatively identifying invasive tumor margins due to their infiltrative nature. Incomplete excision usually leads to early recurrence, while aggressive resection may injure adjacent functional tissues. Herein, we report a pH responsive ratiometric surface-enhanced Raman scattering (SERRS) probe that determined physiological pHs with a high sensitivity and tissue penetration depth via an innovative mechanism named spatial orientation induced intramolecular energy transfer (SOIET). Due to the positive correlation between tumor acidity and malignancy, an acidic margin-guided surgery strategy was implemented in live animal models by intra-operatively assessing tissue pH/malignancy of the suspicious tissues in tumor cutting edges. This surgery remarkably extended the survival of animal models and minimized their post-surgical complications, showing promise in precisely identifying invasive tumor boundaries and achieving a balance between maximum tumor debulking and minimal functional impairment. A novel pH ratiometrically responsive surface-enhanced resonance Raman scattering (SERRS) probe was developed for tumor acidic margin delineation and image-guided surgery.
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DOI：
10.1073/pnas.0813327106
发表时间：
2009-08-11
影响因子：
11.1
作者：
Zavaleta, Cristina L.;Smith, Bryan R.;Gambhir, Sanjiv S.
通讯作者：
Gambhir, Sanjiv S.
影响因子：
11.2
作者：
Wang YW;Reder NP;Kang S;Glaser AK;Yang Q;Wall MA;Javid SH;Dintzis SM;Liu JTC
通讯作者：
Liu JTC
荧光和 SERS 成像可同时绝对定量活细胞中的多种 miRNA
影响因子：
7.4
作者：
Ye, Sujuan;Li, Xiaoxiao;Tang, Bo
通讯作者：
Tang, Bo
肿瘤微环境产生的酸度驱动局部侵袭。
影响因子：
11.2
作者：
Estrella V;Chen T;Lloyd M;Wojtkowiak J;Cornnell HH;Ibrahim-Hashim A;Bailey K;Balagurunathan Y;Rothberg JM;Sloane BF;Johnson J;Gatenby RA;Gillies RJ
通讯作者：
Gillies RJ
影响因子：
11.2
作者：
Rohani, Nazanin;Hao, Liangliang;Gertler, Frank B.
通讯作者：
Gertler, Frank B.