Anteroventral bed nuclei of the stria terminalis neurocircuitry: Towards an integration of HPA axis modulation with coping behaviors - Curt Richter Award Paper 2017.
Anteroventral bed nuclei of the stria terminalis neurocircuitry: Towards an integration of HPA axis modulation with coping behaviors - Curt Richter Award Paper 2017.
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DOI：
10.1016/j.psyneuen.2017.12.005
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发表时间：
2018-03
影响因子：
3.7
通讯作者：
Johnson SB
中科院分区：
文献类型：
--
作者：
Radley JJ;Johnson SB
边缘前脑中相互连接的细胞群网络调节下丘脑-垂体-肾上腺（HPA）轴激活和对情绪压力体验的行为反应，这些系统的慢性破坏与精神疾病的发病机制有关。一个重大的挑战是解开的电路和机制，提供HPA活性的调节，因为这些边缘前脑区域不提供任何直接的神经支配的HPA效应细胞群在室旁下丘脑（PVH）。此外，关于内分泌和行为反应如何整合的信息仍然不清楚。在这里，我们总结了我们的实验室工作表明，前腹（AV）床核的终纹（BST）作为边缘前脑和PVH之间的会聚点，接收和协调上游的影响，并抑制HPA轴输出响应不可避免的压力。最近的研究强调了avBST的更广泛的调节作用，即协调HPA抑制影响，同时通过不同的途径抑制被动行为反应。avBST的独特定位是传达由慢性应激暴露引起的内分泌和行为改变，如HPA轴过度活跃和被动应对策略增加，这可能是由上游边缘皮质区域的突触重组引起的。我们讨论了这些研究如何提供新的见解，以了解系统水平的组织压力反应电路，应对方式的神经生物学，和BST电路功能障碍的压力相关的精神疾病。
A network of interconnected cell groups in the limbic forebrain regulates hypothalamic-pituitary-adrenal (HPA) axis activation and behavioral responses to emotionally stressful experiences, and chronic disruption of these systems chronically is implicated in the pathogenesis of psychiatric illnesses. A significant challenge has been to unravel the circuitry and mechanisms providing for regulation of HPA activity, as these limbic forebrain regions do not provide any direct innervation of HPA effector cell groups in the paraventricular hypothalamus (PVH). Moreover, information regarding how endocrine and behavioral responses are integrated has remained obscure. Here we summarize work from our laboratory showing that anteroventral (av) bed nuclei of the stria terminalis (BST) acts as a point of convergence between the limbic forebrain and PVH, receiving and coordinating upstream influences, and restraining HPA axis output in response to inescapable stressors. Recent studies highlight a more expansive modulatory role for avBST as one that coordinates HPA-inhibitory influences while concurrently suppressing passive behavioral responses via divergent pathways. avBST is uniquely positioned to convey endocrine and behavioral alterations resulting from chronic stress exposure, such as HPA axis hyperactivity and increased passive coping strategies, that may result from synaptic reorganization in upstream limbic cortical regions. We discuss how these studies give new insights into understanding the systems-level organization of stress response circuitry, the neurobiology of coping styles, and BST circuit dysfunction in stress-related psychiatric disorders.
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