Shortened telomere length is associated with increased risk of cancer: a meta-analysis.
Shortened telomere length is associated with increased risk of cancer: a meta-analysis.
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DOI：
10.1371/journal.pone.0020466
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Wei Q
中科院分区：
文献类型：
--
作者：
Ma H;Zhou Z;Wei S;Liu Z;Pooley KA;Dunning AM;Svenson U;Roos G;Hosgood HD 3rd;Shen M;Wei Q
端粒在维持染色体完整性和稳定性中发挥着关键作用，端粒缩短参与恶性肿瘤的发生和进展。一系列流行病学研究探讨了端粒缩短与癌症风险之间的关联，但研究结果仍然相互矛盾。一项荟萃分析纳入了由来自 21 篇出版物的 11,255 例病例和 13,101 例对照组成的数据集，以评估总体癌症风险或癌症特定风险与相对端粒长度之间的关联。分别通过基于 χ2 的 Q 统计检验和 Egger 检验进一步评估研究之间的异质性及其发表偏倚。结果表明，与较长的端粒相比，较短的端粒与癌症风险显着相关（OR = 1.35，95% CI = 1.14–1.60）。在按肿瘤类型进行的分层分析中，这种相关性在膀胱癌（OR = 1.84，95% CI = 1.38–2.44）、肺癌（OR = 2.39，95% CI = 1.18–4.88）、吸烟相关癌症（OR = 2.25， 95% CI = 1.83–2.78）、消化系统癌症（OR = 1.69，95% CI = 1.53–1.87）和泌尿生殖系统癌症（OR = 1.73，95% CI = 1.12–2.67）。此外，结果还表明，在针对白种人受试者、亚洲受试者、回顾性设计、医院对照和较小样本量的研究中，相对端粒长度与总体癌症风险之间的关联具有统计学意义。漏斗图和 Egger 检验表明当前荟萃分析不存在发表偏倚（P = 0.532）。这项荟萃分析的结果表明，端粒缩短的存在可能是人类癌症易感性的一个标志，但有必要进行更大规模、设计良好的前瞻性研究来证实这些发现。
Telomeres play a key role in the maintenance of chromosome integrity and stability, and telomere shortening is involved in initiation and progression of malignancies. A series of epidemiological studies have examined the association between shortened telomeres and risk of cancers, but the findings remain conflicting. A dataset composed of 11,255 cases and 13,101 controls from 21 publications was included in a meta-analysis to evaluate the association between overall cancer risk or cancer-specific risk and the relative telomere length. Heterogeneity among studies and their publication bias were further assessed by the χ2-based Q statistic test and Egger's test, respectively. The results showed that shorter telomeres were significantly associated with cancer risk (OR = 1.35, 95% CI = 1.14–1.60), compared with longer telomeres. In the stratified analysis by tumor type, the association remained significant in subgroups of bladder cancer (OR = 1.84, 95% CI = 1.38–2.44), lung cancer (OR = 2.39, 95% CI = 1.18–4.88), smoking-related cancers (OR = 2.25, 95% CI = 1.83–2.78), cancers in the digestive system (OR = 1.69, 95% CI = 1.53–1.87) and the urogenital system (OR = 1.73, 95% CI = 1.12–2.67). Furthermore, the results also indicated that the association between the relative telomere length and overall cancer risk was statistically significant in studies of Caucasian subjects, Asian subjects, retrospective designs, hospital-based controls and smaller sample sizes. Funnel plot and Egger's test suggested that there was no publication bias in the current meta-analysis (P = 0.532). The results of this meta-analysis suggest that the presence of shortened telomeres may be a marker for susceptibility to human cancer, but single larger, well-design prospective studies are warranted to confirm these findings.
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影响因子：
5.7
作者：
Gorgoulis, VG;Koutroumbi, EN;Kittas, C
通讯作者：
Kittas, C
影响因子：
6.5
作者：
Fern, L;Pallis, M;Byrne, J
通讯作者：
Byrne, J
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
DOI：
10.1073/pnas.112515399
发表时间：
2002-06-11
影响因子：
11.1
作者：
Artandi, SE;Alson, S;DePinho, RA
通讯作者：
DePinho, RA
影响因子：
64.5
作者：
Hemann, MT;Strong, MA;Greider, CW
通讯作者：
Greider, CW