Parameter-Dependency of Low-Intensity Vibration for Wound Healing in Diabetic Mice.
Parameter-Dependency of Low-Intensity Vibration for Wound Healing in Diabetic Mice.
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DOI：
10.3389/fbioe.2021.654920
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发表时间：
2021
影响因子：
5.7
通讯作者：
Koh TJ
中科院分区：
文献类型：
--
作者：
Roberts RE;Bilgen O;Kineman RD;Koh TJ
Chronic wounds in diabetic patients represent an escalating health problem, leading to significant morbidity and mortality. Our group previously reported that whole body low-intensity vibration (LIV) can improve angiogenesis and wound healing in diabetic mice. The purpose of the current study was to determine whether effects of LIV on wound healing are frequency and/or amplitude dependent. Wound healing was assessed in diabetic (db/db) mice exposed to one of four LIV protocols with different combinations of two acceleration magnitudes (0.3 and 0.6 g) and two frequencies (45 and 90 Hz) or in non-vibration sham controls. The low acceleration, low frequency protocol (0.3 g and 45 Hz) was the only one that improved wound healing, increasing angiogenesis and granulation tissue formation, leading to accelerated re-epithelialization and wound closure. Other protocols had little to no impact on healing with some evidence that 0.6 g accelerations negatively affected wound closure. The 0.3 g, 45 Hz protocol also increased levels of insulin-like growth factor-1 and tended to increase levels of vascular endothelial growth factor in wounds, but had no effect on levels of basic fibroblast growth factor or platelet derived growth factor-bb, indicating that this LIV protocol induces specific growth factors during wound healing. Our findings demonstrate parameter-dependent effects of LIV for improving wound healing that can be exploited for future mechanistic and therapeutic studies.
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影响因子：
17.1
作者：
Eming SA;Martin P;Tomic-Canic M
通讯作者：
Tomic-Canic M
DOI：
10.21010/ajtcam.v14i4s.6
发表时间：
2017
期刊：
African journal of traditional, complementary, and alternative medicines : AJTCAM
影响因子：
--
作者：
Sá-Caputo D;Paineiras-Domingos L;Carvalho-Lima R;Dias-Costa G;de Paiva PC;de Azeredo CF;Carmo RCR;Dionello CF;Moreira-Marconi E;Frederico ÉHFF;Sousa-Gonçalves CR;Morel DS;Paiva DN;Avelar NCP;Lacerda AC;Magalhães CEV;Castro LS;Presta GA;de Paoli S;Sañudo B;Bernardo-Filho M
通讯作者：
Bernardo-Filho M
在人类参与者中，在低强度振动期间，皮肤血流增加：使用短时傅立叶变换对控制机制的分析。
影响因子：
3.7
作者：
Tzen YT;Weinheimer-Haus EM;Corbiere TF;Koh TJ
通讯作者：
Koh TJ
影响因子：
3.7
作者：
Weinheimer-Haus EM;Judex S;Ennis WJ;Koh TJ
通讯作者：
Koh TJ
影响因子：
5.4
作者：
Maloney-Hinds, Colleen;Petrofsky, Jerrold S.;Hessinger, David A.
通讯作者：
Hessinger, David A.