Drug discovery through the isolation of natural products from Burkholderia.
Drug discovery through the isolation of natural products from Burkholderia.
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DOI：
10.1080/17460441.2021.1877655
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发表时间：
2021-07
影响因子：
6.3
通讯作者：
Smith, Leif
中科院分区：
文献类型：
--
作者：
Foxfire, Adam;Buhrow, Andrew Riley;Orugunty, Ravi S.;Smith, Leif
关键词：
抗生素耐药性病原体的威胁日益增加，迫切需要发现新的抗生素来对抗它们。伯克霍尔德氏菌属是革兰氏阴性、非孢子形成菌属。虽然它们无处不在，能够在植物和地下水中生长，但它们主要是土壤生物。这些包括更致命的伯克霍尔德氏菌，如鼻疽伯克霍尔德氏菌、类鼻疽伯克霍尔德氏菌和洋葱伯克霍尔德氏菌复合体（BCC）。本文综述了近年来伯克霍尔德菌属天然产物的研究进展。作者还涵盖了对来自伯克霍尔德氏菌的天然产物进行的药物发现工作的研究。虽然伯克霍尔德氏菌具有少量的致病性物种，但该属的大多数是无毒的，并且该属的几乎所有成员都能够产生有用的抗微生物产品，这可能导致开发针对感染性疾病的新型疗法。由于耐药性病原体的不断增加的流行，加上新抗生素发现的减少，迫切需要发现新的抗生素。
The increasing threat of antibiotic resistant pathogens makes it imperative that new antibiotics to combat them are discovered. Burkholderia is a genus of Gram-negative, non-sporulating bacteria. While ubiquitous and capable of growing within plants and groundwater, they are primarily soil-dwelling organisms. These include the more virulent forms of Burkholderia such as Burkholderia mallei, Burkholderia pseudomallei, and the Burkholderia cepacia complex (Bcc). This review provides a synopsis of current research on the natural products isolated from the genus Burkholderia. The authors also cover the research on the drug discovery efforts that have been performed on the natural products derived from Burkholderia. Though Burkholderia has a small number of pathogenic species, the majority of the genus is avirulent and almost all members of the genus are capable of producing useful antimicrobial products that could potentially lead to the development of novel therapeutics against infectious diseases. The need for discovery of new antibiotics is urgent due to the ever-increasing prevalence of antibiotic-resistant pathogens, coupled with the decline in the discovery of new antibiotics.
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DOI：
10.1099/00207713-51-4-1481
发表时间：
2001-07-01
影响因子：
2.8
作者：
Coenye, T;Mahenthiralingam, E;Vandamme, P
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影响因子：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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