The plant Polycomb repressive complex 1 (PRC1) existed in the ancestor of seed plants and has a complex duplication history.
The plant Polycomb repressive complex 1 (PRC1) existed in the ancestor of seed plants and has a complex duplication history.
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DOI：
10.1186/s12862-015-0319-z
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发表时间：
2015-03-13
影响因子：
3.4
通讯作者：
Snel B
中科院分区：
文献类型：
--
作者：
Berke L;Snel B
Polycomb 抑制复合物 1 (PRC1) 是植物发育必需的蛋白质复合物。它催化组蛋白 H2A 泛素化，这是转录抑制机制的重要组成部分。拟南芥植物中 PRC1 亚基的缺失会导致严重的发育缺陷。 PRC1 植物的许多方面都难以捉摸，包括其起源和系统发育分布。我们通过敏感的系统发育方法和来自先前未采样的分类群的新测序的植物基因组，建立了植物 PRC1 亚基（LHP1、Ring1a-b、Bmi1a-c、EMF1 和 VRN1）的进化史。我们表明，所有 PRC1 核心亚基都存在于裸子植物中，比之前认为的更早，并且 VRN1 是最近添加的，仅在双子叶植物中发现。叶绿植物、苔藓植物、石松植物和单叶植物中单个亚基的保留表明它们可以兼职作为其他复合体或过程的一部分。此外，我们发现大多数 PRC1 亚基经历了复杂的、富含重复的历史，这在十字花科和其他真双子叶植物之间存在显着差异。 PRC1 存在于种子植物的最后一个共同祖先中，它可能发挥着重要的调节作用，帮助它们的辐射。 LHP1、Ring1 和 Bmi1 在苔藓、石松植物和单节植物中的存在也表明存在原始但有功能的 PRC1。本文的在线版本 (doi:10.1186/s12862-015-0319-z) 包含补充材料，可供授权用户使用。
Polycomb repressive complex 1 (PRC1) is an essential protein complex for plant development. It catalyzes ubiquitination of histone H2A that is an important part of the transcription repression machinery. Absence of PRC1 subunits in Arabidopsis thaliana plants causes severe developmental defects. Many aspects of the plant PRC1 are elusive, including its origin and phylogenetic distribution. We established the evolutionary history of the plant PRC1 subunits (LHP1, Ring1a-b, Bmi1a-c, EMF1, and VRN1), enabled by sensitive phylogenetic methods and newly sequenced plant genomes from previously unsampled taxonomic groups. We showed that all PRC1 core subunits exist in gymnosperms, earlier than previously thought, and that VRN1 is a recent addition, found exclusively in eudicots. The retention of individual subunits in chlorophytes, mosses, lycophytes and monilophytes indicates that they can moonlight as part of other complexes or processes. Moreover, we showed that most PRC1 subunits underwent a complex, duplication-rich history that differs significantly between Brassicaceae and other eudicots. PRC1 existed in the last common ancestor of seed plants where it likely played an important regulatory role, aiding their radiation. The presence of LHP1, Ring1 and Bmi1 in mosses, lycophytes and monilophytes also suggests the presence of a primitive yet functional PRC1. The online version of this article (doi:10.1186/s12862-015-0319-z) contains supplementary material, which is available to authorized users.
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影响因子：
14.9
作者：
Flicek P;Amode MR;Barrell D;Beal K;Billis K;Brent S;Carvalho-Silva D;Clapham P;Coates G;Fitzgerald S;Gil L;Girón CG;Gordon L;Hourlier T;Hunt S;Johnson N;Juettemann T;Kähäri AK;Keenan S;Kulesha E;Martin FJ;Maurel T;McLaren WM;Murphy DN;Nag R;Overduin B;Pignatelli M;Pritchard B;Pritchard E;Riat HS;Ruffier M;Sheppard D;Taylor K;Thormann A;Trevanion SJ;Vullo A;Wilder SP;Wilson M;Zadissa A;Aken BL;Birney E;Cunningham F;Harrow J;Herrero J;Hubbard TJ;Kinsella R;Muffato M;Parker A;Spudich G;Yates A;Zerbino DR;Searle SM
通讯作者：
Searle SM
影响因子：
14.9
作者：
Durek P;Schmidt R;Heazlewood JL;Jones A;MacLean D;Nagel A;Kersten B;Schulze WX
通讯作者：
Schulze WX
影响因子：
11.6
作者：
Aubert, D;Chen, LJ;Sung, ZR
通讯作者：
Sung, ZR
影响因子：
27.5
作者：
Bratzel, Fabian;Yang, Chao;Calonje, Myriam
通讯作者：
Calonje, Myriam
DOI：
10.1073/pnas.1118678109
发表时间：
2012-05-01
影响因子：
11.1
作者：
Beh, Leslie Y.;Colwell, Lucy J.;Francis, Nicole J.
通讯作者：
Francis, Nicole J.