Columnar connectivity and laminar processing in cat primary auditory cortex.
Columnar connectivity and laminar processing in cat primary auditory cortex.
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DOI：
10.1371/journal.pone.0009521
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发表时间：
2010-03-03
期刊：
影响因子：
3.7
通讯作者：
Schreiner CE
中科院分区：
文献类型：
--
作者：
Atencio CA;Schreiner CE
径向层内和层间连接在初级听觉皮层 (AI) 中形成基本微电路，提取声音信息并将其分发到皮层和皮层下网络。尽管该微电路的结构已知，但我们不知道层之间的功能连接如何与层流处理相关。我们通过同时记录猫 AI 中单个神经元对宽带动态移动纹波刺激的响应，研究了该柱状微电路中功能连接性和感受野特性之间的关系。我们使用频谱时间感受野（STRF）来估计感受野参数与神经元对之间的功能连接之间的关系。通过互协方差分析获得的层间连接反映了从丘脑输入层到皮质输出层的信息流的一致模式。层内神经元对和颗粒上层的连接强度和 STRF 相似性最大，而层间投射的连接强度和 STRF 相似性较弱。层间连接强度与多个 STRF 参数共同变化：特征选择性、刺激包络的锁相、最佳时间调制频率和最佳频谱调制频率。垂直和水平连接的连接属性和感受野关系不同。因此，粒上层的局部加工方式与粒下层的局部加工方式不同。因此，听觉皮层中的特定连接模式塑造了信息流，并限制了规范柱状听觉微电路中频谱时间处理转换的进展。
Radial intra- and interlaminar connections form a basic microcircuit in primary auditory cortex (AI) that extracts acoustic information and distributes it to cortical and subcortical networks. Though the structure of this microcircuit is known, we do not know how the functional connectivity between layers relates to laminar processing. We studied the relationships between functional connectivity and receptive field properties in this columnar microcircuit by simultaneously recording from single neurons in cat AI in response to broadband dynamic moving ripple stimuli. We used spectrotemporal receptive fields (STRFs) to estimate the relationship between receptive field parameters and the functional connectivity between pairs of neurons. Interlaminar connectivity obtained through cross-covariance analysis reflected a consistent pattern of information flow from thalamic input layers to cortical output layers. Connection strength and STRF similarity were greatest for intralaminar neuron pairs and in supragranular layers and weaker for interlaminar projections. Interlaminar connection strength co-varied with several STRF parameters: feature selectivity, phase locking to the stimulus envelope, best temporal modulation frequency, and best spectral modulation frequency. Connectivity properties and receptive field relationships differed for vertical and horizontal connections. Thus, the mode of local processing in supragranular layers differs from that in infragranular layers. Therefore, specific connectivity patterns in the auditory cortex shape the flow of information and constrain how spectrotemporal processing transformations progress in the canonical columnar auditory microcircuit.
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DOI：
10.1523/jneurosci.2093-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Barbour DL;Callaway EM
通讯作者：
Callaway EM
影响因子：
16.2
作者：
Atencio, Craig A.;Sharpee, Tatyana O.;Schreiner, Christoph E.
通讯作者：
Schreiner, Christoph E.
影响因子：
25
作者：
Alonso, JM;Martinez, LM
通讯作者：
Martinez, LM
影响因子：
9.8
作者：
Bureau, Ingrid;von Saint Paul, Francisca;Svoboda, Karel
通讯作者：
Svoboda, Karel
影响因子：
56.9
作者：
deCharms, RC;Blake, DT;Merzenich, MM
通讯作者：
Merzenich, MM