Virtual reality exposure therapy as treatment for pain catastrophizing in fibromyalgia patients: proof-of-concept study (Study Protocol).
Virtual reality exposure therapy as treatment for pain catastrophizing in fibromyalgia patients: proof-of-concept study (Study Protocol).
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DOI：
10.1186/1471-2474-12-85
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发表时间：
2011-04-30
影响因子：
2.3
通讯作者：
Louw QA
中科院分区：
文献类型：
--
作者：
Morris LD;Grimmer-Somers KA;Spottiswoode B;Louw QA
尽管运动目前被认为是纤维肌痛综合征（FMS）最有效的治疗策略之一；由于患者依从性差，运动作为FMS治疗在现实中的实施受到很大阻碍。疼痛灾难化是FMS患者依从性差的关键预测因素，这一推断证明了考虑改变疼痛灾难化可以提高FMS患者对运动的依从性。本研究的目的是为开发和测试一种新的虚拟现实暴露疗法（VRET）方案，作为FMS患者运动相关疼痛灾难的治疗提供概念验证。将进行两项相互关联的实验研究。研究1旨在客观地确定当灾难化FMS受试者暴露于运动活动的视觉效果时，与疼痛灾难化相关的脑功能区域是否发生神经生理变化。研究2旨在确定运动活动视觉暴露作为FMS受试者运动相关疼痛灾难化治疗的初步疗效和可行性。将从南非开普敦Tygerberg医院的一组FMS患者中选择20名受试者，随机分配到VRET（干预）组或等候名单（对照组）组。研究1将使用功能磁共振成像（fMRI）收集受试者的基线神经生理活动。在研究2中，将使用功能磁共振成像（客观）和疼痛灾难化量表（主观）来测量疼痛灾难化的临床改善。前提是，如果让FMS患者接触各种运动活动的视觉效果，会触发与疼痛灾难相关的功能性大脑区域；然后作为一种治疗方法，使用VRET程序反复暴露于运动活动的视觉效果可能会减少FMS患者与运动相关的疼痛灾难。概念验证要么被建立，要么被否定。预计该项目的结果将彻底改变FMS和疼痛灾难化研究，并在未来帮助卫生专业人员和FMS患者减少对FMS管理的沮丧。PACTR201011000264179
Albeit exercise is currently advocated as one of the most effective management strategies for fibromyalgia syndrome (FMS); the implementation of exercise as a FMS treatment in reality is significantly hampered by patients' poor compliance. The inference that pain catastrophizing is a key predictor of poor compliance in FMS patients, justifies considering the alteration of pain catastrophizing in improving compliance towards exercises in FMS patients. The aim of this study is to provide proof-of-concept for the development and testing of a novel virtual reality exposure therapy (VRET) program as treatment for exercise-related pain catastrophizing in FMS patients. Two interlinked experimental studies will be conducted. Study 1 aims to objectively ascertain if neurophysiological changes occur in the functional brain areas associated with pain catastrophizing, when catastrophizing FMS subjects are exposed to visuals of exercise activities. Study 2 aims to ascertain the preliminary efficacy and feasibility of exposure to visuals of exercise activities as a treatment for exercise-related pain catastrophizing in FMS subjects. Twenty subjects will be selected from a group of FMS patients attending the Tygerberg Hospital in Cape Town, South Africa and randomly allocated to either the VRET (intervention) group or waiting list (control) group. Baseline neurophysiological activity for subjects will be collected in study 1 using functional magnetic resonance imaging (fMRI). In study 2, clinical improvement in pain catastrophizing will be measured using fMRI (objective) and the pain catastrophizing scale (subjective). The premise is if exposing FMS patients to visuals of various exercise activities trigger the functional brain areas associated with pain catastrophizing; then as a treatment, repeated exposure to visuals of the exercise activities using a VRET program could possibly decrease exercise-related pain catastrophizing in FMS patients. Proof-of-concept will either be established or negated. The results of this project are envisaged to revolutionize FMS and pain catastrophizing research and in the future, assist health professionals and FMS patients in reducing despondency regarding FMS management. PACTR201011000264179
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影响因子：
4.9
作者：
Häuser W;Klose P;Langhorst J;Moradi B;Steinbach M;Schiltenwolf M;Busch A
通讯作者：
Busch A
影响因子：
2.3
作者：
Jones, Kim D.;Liptan, Ginevra L.
通讯作者：
Liptan, Ginevra L.
影响因子：
5.1
作者：
Oliver, K;Cronan, T
通讯作者：
Cronan, T
影响因子：
3.6
作者：
Roelofs, J;Goubert, L;Crombez, G
通讯作者：
Crombez, G
DOI：
10.1016/j.jbtep.2007.07.007
发表时间：
2008-09-01
影响因子：
1.8
作者：
Parsons, Thomas D.;Rizzo, Albert A.
通讯作者：
Rizzo, Albert A.