Effect of lipid-lowering therapy with atorvastatin on atherosclerotic aortic plaques detected by noninvasive magnetic resonance imaging.
Effect of lipid-lowering therapy with atorvastatin on atherosclerotic aortic plaques detected by noninvasive magnetic resonance imaging.
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阿托伐他汀降脂治疗对无创磁共振成像检测的动脉粥样硬化斑块的影响。
DOI：
10.1016/j.jacc.2004.11.039
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发表时间：
2005
影响因子：
24
通讯作者：
F. Ohsuzu
中科院分区：
文献类型：
--
作者：
A. Yonemura;Y. Momiyama;Z. Fayad;M. Ayaori;Reiko Ohmori;K. Higashi;T. Kihara;Shojiro Sawada;N. Iwamoto;M. Ogura;Hiroaki Taniguchi;M. Kusuhara;M. Nagata;H. Nakamura;S. Tamai;F. Ohsuzu
我们试图阐明20 mg阿托伐他汀与5 mg阿托伐他汀对胸腹主动脉斑块的影响。背景：核磁共振成像(MRI)显示辛伐他汀可使胸主动脉斑块消退。然而，不同剂量的他汀类药物的作用还没有被评估。方法利用MRI，我们观察了20 mg和5 mg阿托伐他汀对40例高胆固醇血症患者胸腹主动脉斑块的影响，这些患者被随机分为两组。从基线到治疗12个月，通过动脉粥样硬化病变的管壁厚度和管壁面积的变化来评估治疗效果。结果20 mg剂量的低密度脂蛋白胆固醇的降幅大于5 mg剂量(−47%vs.−34%，p<；0.001)。虽然20毫克和5毫克降低了C反应蛋白水平(−为47%，−为28%)，但两种剂量之间的C反应蛋白降低程度没有差别。20 mg剂量可降低胸主动脉斑块的VWT和VWa(−分别为12%和18%，p<；0.001)，而5 mg不能降低胸主动脉斑块的VWT和VWA(+1%和+4%)。对于腹主动脉斑块，即使20毫克也不能减少VWT或VWA(−分别为1%和+3%)，但5毫克治疗可观察到进展(分别为+5%和+12%，p<；0.01)。值得注意的是，胸主动脉斑块的消退程度与低密度脂蛋白(r=0.64)和C反应蛋白(r=0.49)的降低有关。腹主动脉斑块的改变与低密度脂蛋白的降低仅呈弱相关(r=0.34)，与年龄呈正相关(r=0.41)。结论阿托伐他汀治疗1年后，胸主动脉斑块消退，低密度脂蛋白显著降低，但仅延缓腹主动脉斑块的进展。胸主动脉斑块和腹主动脉斑块对降脂的敏感性可能不同。
ObjectivesWe sought to elucidate the effects of 20-mg versus 5-mg atorvastatin on thoracic and abdominal aortic plaques.BackgroundRegression of thoracic aortic plaques by simvastatin was demonstrated using magnetic resonance imaging (MRI). However, the effects of different doses of statin have not been assessed.MethodsUsing MRI, we investigated the effects of 20-mg versus 5-mg atorvastatin on thoracic and abdominal aortic plaques in 40 hypercholesterolemic patients who were randomized to receive either dose. Treatment effects were evaluated as changes in vessel wall thickness (VWT) and vessel wall area (VWA) of atherosclerotic lesions from baseline to 12 months of treatment.ResultsThe 20-mg dose induced a greater low-density lipoprotein (LDL) cholesterol reduction than did the 5-mg dose (−47% vs. −34%, p < 0.001). Although 20 mg and 5 mg reduced C-reactive protein (CRP) levels (−47% and −28%), the degree of CRP reduction did not differ between the two doses. The 20-mg dose reduced VWT and VWA of thoracic aortic plaques (−12% and −18%, p < 0.001), whereas 5 mg did not (+1% and +4%). Regarding abdominal aortic plaques, even 20 mg could not reduce VWT or VWA (−1% and +3%), but instead progression was observed with 5-mg treatment (+5% and +12%, p < 0.01). Notably, the degree of plaque regression in thoracic aorta correlated with LDL cholesterol (r = 0.64) and CRP (r = 0.49) reductions. Although changes in abdominal aortic plaques only weakly correlated with LDL cholesterol reduction (r = 0.34), they correlated with age (r = 0.41).ConclusionsOne-year 20-mg atorvastatin treatment induced regression of thoracic aortic plaques with marked LDL cholesterol reduction, whereas it resulted in only retardation of plaque progression in abdominal aorta. Thoracic and abdominal aortic plaques may have different susceptibilities to lipid lowering.
使用黑血磁共振成像进行无创体内人冠状动脉管腔和管壁成像。
影响因子：
37.8
作者：
Fayad,ZA;Fuster,V;Fallon,JT;Jayasundera,T;Worthley,SG;Helft,G;Aguinaldo,JG;Badimon,JJ;Sharma,SK
通讯作者：
Sharma,SK
影响因子：
5.3
作者：
Worthley, SG;Helft, G;Badimon, JJ
通讯作者：
Badimon, JJ
影响因子：
37.8
作者：
Fayad, ZA;Nahar, T;Fuster, V
通讯作者：
Fuster, V