High-Resolution Imaging by Adaptive Optics Scanning Laser Ophthalmoscopy Reveals Two Morphologically Distinct Types of Retinal Hard Exudates.
High-Resolution Imaging by Adaptive Optics Scanning Laser Ophthalmoscopy Reveals Two Morphologically Distinct Types of Retinal Hard Exudates.
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DOI：
10.1038/srep33574
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发表时间：
2016-09-19
影响因子：
4.6
通讯作者：
Sonoda KH
中科院分区：
文献类型：
--
作者：
Yamaguchi M;Nakao S;Kaizu Y;Kobayashi Y;Nakama T;Arima M;Yoshida S;Oshima Y;Takeda A;Ikeda Y;Mukai S;Ishibashi T;Sonoda KH
尸检标本的组织学研究将硬渗出物表征为富含脂质的巨噬细胞或非细胞物质（包括脂质和蛋白质物质（透明物质））的组成。然而，由于现有设备的分辨率不足，尚未检查活体患者的硬性渗出物特征。在这项研究中，我们使用自适应光学扫描激光检眼镜（AO-SLO）检查视网膜血管疾病患者的硬性渗出物的特征。使用AO-SLO的高分辨率成像能够将视网膜硬性渗出物形态学分类为两种类型，这两种类型在眼底检查或光谱域光学相干断层扫描（SD-OCT）中无法区分。一种为圆形，由球形颗粒聚集而成（颗粒平均直径：26.9 ± 4.4 μm）。另一种被称为不规则类型，包括不规则形状的超反射沉积。圆形硬性渗出区视网膜厚度明显大于不规则形硬性渗出区（P = 0.01 →0.02）。AO-SLO对视网膜硬性渗出物的鉴别有助于了解视网膜血管性疾病的发病机制和临床预后。
Histological studies from autopsy specimens have characterized hard exudates as a composition of lipid-laden macrophages or noncellular materials including lipid and proteinaceous substances (hyaline substances). However, the characteristics of hard exudates in living patients have not been examined due to insufficient resolution of existing equipment. In this study, we used adaptive optics scanning laser ophthalmoscopy (AO-SLO) to examine the characteristics of hard exudates in patients with retinal vascular diseases. High resolution imaging using AO-SLO enables morphological classification of retinal hard exudates into two types, which could not be distinguished either on fundus examination or by spectral domain optical coherence tomography (SD-OCT). One, termed a round type, consisted of an accumulation of spherical particles (average diameter of particles: 26.9 ± 4.4 μm). The other, termed an irregular type, comprised an irregularly shaped hyper-reflective deposition. The retinal thickness in regions with round hard exudates was significantly greater than the thickness in regions with irregular hard exudates (P = 0.01 →0.02). This differentiation of retinal hard exudates in patients by AO-SLO may help in understanding the pathogenesis and clinical prognosis of retinal vascular diseases.
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影响因子：
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作者：
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通讯作者：
Tabas I
影响因子：
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作者：
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通讯作者：
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DOI：
10.1097/iae.0b013e318183571e
发表时间：
2008-11-01
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Rosen, Richard B.
DOI：
10.1007/s00417-014-2760-x
发表时间：
2015-06-01
影响因子：
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作者：
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通讯作者：
Ishibashi, Tatsuro