Representation of attended versus remembered locations in prefrontal cortex.
Representation of attended versus remembered locations in prefrontal cortex.
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DOI：
10.1371/journal.pbio.0020365
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发表时间：
2004-11
期刊：
影响因子：
9.8
通讯作者：
Wise SP
中科院分区：
文献类型：
--
作者：
Lebedev MA;Messinger A;Kralik JD;Wise SP
前额叶皮质(PF)的大量研究，特别是在非人类灵长类动物中，一直集中在它在维持短期记忆中的主要功能的理论上，神经生理学家经常根据这一理论来解释PF的延迟期活动。然而，神经成像结果表明，PF的功能超出了维持记忆的范围，包括注意力的各个方面，如监测和选择信息。为了探索对PF延迟期活动的另一种解释，我们研究了猴子在记住不同的、未标记的位置时，对标记一个位置的刺激的单个PF神经元的放电率。这两个位置都是眼球跳动的潜在目标。尽管这项任务对短期记忆有强烈的要求，但最大比例的PF神经元代表了注意的位置，而不是记忆的位置。目前的发现表明，短时记忆功能不能解释所探索的部分PF的延迟期活动的全部甚至大部分。相反，PF的延迟期活动可能对注意选择过程有更大的贡献。前额叶区域神经元的持续活动通常被认为是短期记忆的基础。Mikhail Lebedev和他的同事提供了另一种解释
A great deal of research on the prefrontal cortex (PF), especially in nonhuman primates, has focused on the theory that it functions predominantly in the maintenance of short-term memories, and neurophysiologists have often interpreted PF's delay-period activity in the context of this theory. Neuroimaging results, however, suggest that PF's function extends beyond the maintenance of memories to include aspects of attention, such as the monitoring and selection of information. To explore alternative interpretations of PF's delay-period activity, we investigated the discharge rates of single PF neurons as monkeys attended to a stimulus marking one location while remembering a different, unmarked location. Both locations served as potential targets of a saccadic eye movement. Although the task made intensive demands on short-term memory, the largest proportion of PF neurons represented attended locations, not remembered ones. The present findings show that short-term memory functions cannot account for all, or even most, delay-period activity in the part of PF explored. Instead, PF's delay-period activity probably contributes more to the process of attentional selection. Persistent activity of neurons in an area of the frontal lobe - the prefrontal cortex - is often proposed to underlie short- term memory. Mikhail Lebedev and colleagues provide an alternative explanation
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