Innervation patterns of PGP 9.5-positive nerve fibers within the human lumbar vertebra.
Innervation patterns of PGP 9.5-positive nerve fibers within the human lumbar vertebra.
复制标题
PGP 9.5阳性神经纤维的神经纤维神经模式。
DOI：
10.1111/j.1469-7580.2010.01332.x
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发表时间：
2011-03
影响因子：
2.4
通讯作者：
Lotz JC
中科院分区：
文献类型：
--
作者：
Bailey JF;Liebenberg E;Degmetich S;Lotz JC
椎间盘损伤或退变是腰痛的常见原因，但在许多情况下疼痛的具体来源仍然不明确。先前的研究表明，中央椎骨终板受到高度神经支配，可以引起对压力的疼痛反应。为了追踪终板神经的起源，我们使用蛋白质基因产物 9.5 (PGP 9.5) 对神经纤维进行染色，然后量化人类 L4 腰椎内神经分布的空间模式。大多数神经邻近血管壁，因此神经分布与先前建立的血管分布模式非常相似。我们观察到大部分神经通过基椎孔向后进入椎体，并聚集在椎体中心。这些神经沿着营养动脉走行，通过基底椎孔进入椎体，然后向上终板和下终板分支。我们的观察结果支持这样的观点，即在中央终板发现的神经可能起源于伴随营养动脉进入椎体的窦椎神经。我们还用降钙素基因相关蛋白 (CGRP) 对邻近的组织切片进行染色，并注意到与 PGP 9.5 的显着共定位，证实了构成我们分布模式的神经的伤害感受作用。
Intervertebral disc injury or degeneration is a common cause of low back pain, and yet the specific source of pain remains ambiguous in many cases. Previous research indicates that the central vertebral endplate is highly innervated and can elicit pain responses to pressure. In effort to trace the origin of nerves located at the endplate, we used protein gene product 9.5 (PGP 9.5) to stain neurofibers and then quantified the spatial pattern of nerve distribution within a human L4 lumbar vertebra. The majority of nerves were adjacent to blood vessel walls, and consequently the nerve distribution closely resembled previously established vascularity patterns. We observed that the majority of nerves enter the vertebral body posteriorly, via the basivertebral foramen, and cluster in the vertebral center. These nerves follow the course of the nutrient artery, which enters the vertebral body through the basivertebral foramen, then branches toward the superior and inferior endplates. Our observations support the notion that nerves found at the central endplate could originate from sinuvertebral nerves accompanying the nutrient artery into the vertebral body. We also stained neighboring histological sections with calcitonin gene related protein (CGRP) and noted significant co-localization with PGP 9.5, substantiating a nociceptive role for the nerves comprising our distribution pattern.
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影响因子：
1.8
作者：
Gallagher, S;Marras, WS;Burr, D
通讯作者：
Burr, D
影响因子：
3
作者：
Fagan, A;Moore, R;Fraser, R
通讯作者：
Fraser, R
DOI：
10.1302/0301-620x.79b1.6814
发表时间：
1997-01-01
影响因子：
--
作者：
Brown, MF;Hukkanen, MVJ;Polak, JM
通讯作者：
Polak, JM
影响因子：
3
作者：
Antonacci, MD;Hanson, DS;Heggeness, MH
通讯作者：
Heggeness, MH
影响因子：
3
作者：
Adams, MA;Freeman, BJC;Dolan, P
通讯作者：
Dolan, P