A chelicerate-specific burst of nonclassical Dscam diversity.
A chelicerate-specific burst of nonclassical Dscam diversity.
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非经典 Dscam 多样性的螯合物特异性爆发
DOI：
10.1186/s12864-017-4420-0
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发表时间：
2018-01-19
期刊：
影响因子：
4.4
通讯作者：
Jin Y
中科院分区：
文献类型：
--
作者：
Cao G;Shi Y;Zhang J;Ma H;Hou S;Dong H;Hong W;Chen S;Li H;Wu Y;Guo P;Shao X;Xu B;Shi F;Meng Y;Jin Y
BackgroundThe immunoglobulin (Ig) superfamily receptor Down syndrome cell adhesion molecule (Dscam) gene can generate tens of thousands of isoforms via alternative splicing, which is essential for both nervous and immune systems in insects. However, further information is required to develop a comprehensive view ofDscamdiversification across the broad spectrum of Chelicerata clades, a basal branch of arthropods and the second largest group of terrestrial animals.ResultsIn this study, a genome-wide comprehensive analysis ofDscamgenes across Chelicerata species revealed a burst of nonclassicalDscams, categorised into four types—mDscam,sDscamα,sDscamβ, andsDscamγ—based on their size and structure. Although themDscamgene class includes the highest number ofDscamgenes, thesDscamgenes utilise alternative promoters to expand protein diversity. Furthermore, we indicated that the 5′ cassette duplicate is inversely correlated with thesDscamgene duplicate. We showed differential andsDscam- biased expression of nonclassical Dscam isoforms. Thus, the Dscam isoform repertoire across Chelicerata is entirely dominated by the number and expression levels of nonclassicalDscams. Taken together, these data show that Chelicerata evolved a large conserved and lineage-specific repertoire of nonclassical Dscams.ConclusionsThis study showed that arthropods have a large diversified Chelicerata-specific repertoire of nonclassical Dscam isoforms, which are structurally and mechanistically distinct from those of insects. These findings provide a global framework for the evolution of Dscam diversity in arthropods and offer mechanistic insights into the diversification of the clade-specific Ig superfamily repertoire.
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影响因子：
3.4
作者：
Armitage SA;Freiburg RY;Kurtz J;Bravo IG
通讯作者：
Bravo IG
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通讯作者：
Zipursky SL
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Gulia-Nuss M;Nuss AB;Meyer JM;Sonenshine DE;Roe RM;Waterhouse RM;Sattelle DB;de la Fuente J;Ribeiro JM;Megy K;Thimmapuram J;Miller JR;Walenz BP;Koren S;Hostetler JB;Thiagarajan M;Joardar VS;Hannick LI;Bidwell S;Hammond MP;Young S;Zeng Q;Abrudan JL;Almeida FC;Ayllón N;Bhide K;Bissinger BW;Bonzon-Kulichenko E;Buckingham SD;Caffrey DR;Caimano MJ;Croset V;Driscoll T;Gilbert D;Gillespie JJ;Giraldo-Calderón GI;Grabowski JM;Jiang D;Khalil SMS;Kim D;Kocan KM;Koči J;Kuhn RJ;Kurtti TJ;Lees K;Lang EG;Kennedy RC;Kwon H;Perera R;Qi Y;Radolf JD;Sakamoto JM;Sánchez-Gracia A;Severo MS;Silverman N;Šimo L;Tojo M;Tornador C;Van Zee JP;Vázquez J;Vieira FG;Villar M;Wespiser AR;Yang Y;Zhu J;Arensburger P;Pietrantonio PV;Barker SC;Shao R;Zdobnov EM;Hauser F;Grimmelikhuijzen CJP;Park Y;Rozas J;Benton R;Pedra JHF;Nelson DR;Unger MF;Tubio JMC;Tu Z;Robertson HM;Shumway M;Sutton G;Wortman JR;Lawson D;Wikel SK;Nene VM;Fraser CM;Collins FH;Birren B;Nelson KE;Caler E;Hill CA
通讯作者：
Hill CA