S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial.
S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial.
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DOI：
10.1111/j.1530-0277.2011.01547.x
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Halsted CH
中科院分区：
文献类型：
--
作者：
Medici V;Virata MC;Peerson JM;Stabler SP;French SW;Gregory JF 3rd;Albanese A;Bowlus CL;Devaraj S;Panacek EA;Richards JR;Halsted CH
S-腺苷-L-甲硫氨酸 (SAM) 是所有甲基化反应的甲基供体，并调节主要细胞抗氧化剂谷胱甘肽 (GSH) 的合成。先前的实验研究表明，SAM 可能对患有酒精性肝病 (ALD) 的患者有益。本研究的目的是通过为期 24 周的试验确定 SAM 治疗 ALD 的疗效。主要终点是血清转氨酶水平和肝脏组织病理学评分的变化，次要终点是血清蛋氨酸代谢物水平的变化。我们将 37 名 ALD 患者随机分组，每天口服 1.2 克 SAM 或安慰剂。受试者被要求保持戒酒。对 24 名受试者进行基线肝活检，对 14 名受试者进行治疗后肝活检。 SAM 治疗组的空腹血清 SAM 水平随着时间间隔的增加而增加。治疗 24 周后，整个队列显示 AST、ALT 和胆红素水平总体改善，但治疗组之间的任何临床或生化参数均无差异，组内或组间的脂肪变性、炎症、纤维化和 Mallory-Denk 透明小体的肝脏组织病理学评分也没有任何差异或变化。尽管戒酒改善了肝功能，但 24 周的 SAM 治疗在 ALD 治疗方面并不比安慰剂更有效。
S-adenosyl-L-methionine (SAM) is the methyl donor for all methylation reactions and regulates the synthesis of glutathione (GSH), the main cellular antioxidant. Previous experimental studies suggested that SAM may benefit patients with established alcoholic liver diseases (ALD). The aim of this study was to determine the efficacy of SAM in treatment of ALD in a 24 week trial. The primary endpoints were changes in serum aminotransferase levels and liver histopathology scores, and the secondary endpoint was changes in serum levels of methionine metabolites. We randomized 37 patients with ALD to receive 1.2 grams of SAM by mouth or placebo daily. Subjects were required to remain abstinent from alcohol drinking. A baseline liver biopsy was performed in 24 subjects and a post-treatment liver biopsy was performed in 14 subjects. Fasting serum SAM levels were increased over timed intervals in the SAM treatment group. The entire cohort showed an overall improvement of AST, ALT, and bilirubin levels after 24 weeks of treatment but there were no differences between the treatment groups in any clinical or biochemical parameters nor any intra- or intergroup differences or changes in liver histopathology scores for steatosis, inflammation, fibrosis, and Mallory-Denk hyaline bodies. Whereas abstinence improved liver function, twenty-four weeks of therapy with SAM was no more effective than placebo in the treatment of ALD.
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影响因子：
25.7
作者：
Medici, Valentina;Peerson, Janet M.;Stabler, Sally P.;French, Samuel W.;Gregory, Jesse F., III;Virata, Maria Catrina;Albanese, Antony;Bowlus, Christopher L.;Devaraj, Sridevi;Panacek, Edward A.;Rahim, Nazir;Richards, John R.;Rossaro, Lorenzo;Halsted, Charles H.
通讯作者：
Halsted, Charles H.
DOI：
10.1016/s0378-4347(00)84518-1
发表时间：
1985-01-01
期刊：
JOURNAL OF CHROMATOGRAPHY
影响因子：
--
作者：
UBBINK, JB;SERFONTEIN, WJ;DEVILLIERS, LS
通讯作者：
DEVILLIERS, LS
影响因子：
29.4
作者：
Wiesner, R;Edwards, E;Krom, R
通讯作者：
Krom, R
DOI：
10.1111/j.1530-0277.2007.00407.x
发表时间：
2007-07-01
影响因子：
3.2
作者：
Esfandiari, Farah;You, Min;Halsted, Charles H.
通讯作者：
Halsted, Charles H.
影响因子：
--
作者：
Bush, K;Kivlahan, DR;Bradley, KA
通讯作者：
Bradley, KA