High pretreatment serum gamma-glutamyl transpeptidase predicts an inferior outcome in nasopharyngeal carcinoma.
High pretreatment serum gamma-glutamyl transpeptidase predicts an inferior outcome in nasopharyngeal carcinoma.
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高预处理血清γ-谷氨酰转肽酶预示鼻咽癌的预后较差
DOI：
10.18632/oncotarget.18798
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发表时间：
2017-09-15
期刊：
影响因子：
--
通讯作者：
Hu G
中科院分区：
文献类型：
--
作者：
Luo M;Sun W;Wu C;Zhang L;Liu D;Li W;Mei Q;Hu G
Background Gamma-glutamyl transpeptidase (GGT) which plays an important role in tumor initiation, invasion, drug resistance is strongly associated with poor prognosis in patients with cancers. This study was designed to estimate whether pretreatment serum GGT could predict the clinical outcome of nasopharyngeal carcinoma (NPC) patients. Results An optimal cutoff value was identified as 23 U/L for GGT. Univariate analysis and multivariate analysis demonstrated that elevated GGT was correlated with shorter local recurrence-free survival (LRFS) (HR, 4.163; 95% CI, 1.690-10.251; p=0.023), progression-free survival (PFS) (HR, 3.119; 95% CI, 1.955-4.976; p=0.031) and overall survival (OS) (HR, 2.811; 95% CI, 1.614-4.896; p=0.007). Materials and Methods We retrospectively analyzed data from 374 patients with NPC. Kaplan–Meier method was used to calculate and compare the prognosis. The Cox proportional hazards model was applied to carry out univariate and multivariate analyses. Conclusion Pretreatment GGT can be a novel and independent prognostic biomarker for patients with NPC.
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高密度脂蛋白胆固醇作为鼻咽癌患者生存不良的预测因子。
影响因子：
--
作者：
Liu YY;Lin SJ;Chen YY;Liu LN;Bao LB;Tang LQ;Ou JS;Liu ZG;Chen XZ;Xu Y;Ma J;Chan AT;Chen M;Xia YF;Liu WL;Zeng YX;Mai HQ;Zeng MS;Pan JJ;Zhang X
通讯作者：
Zhang X
影响因子：
--
作者：
Hanigan, Marie H.
通讯作者：
Hanigan, Marie H.
影响因子：
8.8
作者：
Hofbauer, S. L.;Stangl, K. I.;de Martino, M.;Lucca, I.;Haitel, A.;Shariat, S. F.;Klatte, T.
通讯作者：
Klatte, T.
影响因子：
4.1
作者：
Bouman, L;Sancéau, J;Bauvois, B
通讯作者：
Bauvois, B
DOI：
10.1073/pnas.89.7.3070
发表时间：
1992-04-01
影响因子：
11.1
作者：
GODWIN, AK;MEISTER, A;ANDERSON, ME
通讯作者：
ANDERSON, ME