High-density lipoprotein cholesterol as a predictor of poor survival in patients with nasopharyngeal carcinoma.
High-density lipoprotein cholesterol as a predictor of poor survival in patients with nasopharyngeal carcinoma.
复制标题
高密度脂蛋白胆固醇作为鼻咽癌患者生存不良的预测因子。
DOI：
10.18632/oncotarget.7160
复制
发表时间：
2016-07-12
期刊：
影响因子：
--
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Liu YY;Lin SJ;Chen YY;Liu LN;Bao LB;Tang LQ;Ou JS;Liu ZG;Chen XZ;Xu Y;Ma J;Chan AT;Chen M;Xia YF;Liu WL;Zeng YX;Mai HQ;Zeng MS;Pan JJ;Zhang X
我们的目的是评估鼻咽癌患者治疗前高密度脂蛋白胆固醇(HDLC)水平对预后的预测价值，并探讨这些脂蛋白对鼻咽癌细胞的可能生物学效应。我们研究了来自三个独立机构的2443例非转移性鼻咽癌患者治疗前高密度脂蛋白胆固醇水平的预后价值。采用COX比例风险模型和对数列检验分析高密度脂蛋白胆固醇水平与总生存期的相关性。采用细胞生长、集落形成和细胞凋亡实验检测高密度脂蛋白对鼻咽癌细胞的生物学功能。所有的统计检验都是双面的。治疗前高密度脂蛋白胆固醇水平的患者与低高密度脂蛋白胆固醇水平的患者相比，其OS降低(P<；0.05)。同样，在晚期(III-IV期)、治疗前高水平的鼻咽癌患者中，OS降低(P<；0.01)。多变量分析表明，在训练队列中，高密度脂蛋白胆固醇是与较短的OS相关的独立预后因素。这些发现在两个独立的验证队列中都得到了证实(P<；0.01)。体外实验表明，高密度脂蛋白可促进细胞增殖、侵袭和集落形成，这在很大程度上依赖于其受体SR-B1的表达。最后，高密度脂蛋白可以通过保护癌细胞免受凋亡来增强化疗耐药性。治疗前高密度脂蛋白胆固醇是影响鼻咽癌患者预后的不良因素。这种作用可能与高密度脂蛋白增强鼻咽癌细胞的增殖、集落形成、迁移和化疗耐药性有关。
We aimed to assess the prognostic value of pretreatment high density lipoprotein cholesterol (HDL-C) levels in patients with nasopharyngeal carcinoma (NPC) and investigate the possible biological effects of these lipoproteins on NPC cells in vitro. We examined the prognostic value of pretreatment HDL-C levels in 2443 patients with non-metastatic NPC from three independent institutions. The Cox proportional hazard model and log-rank test were used to analyze the correlation between HDL-C levels and overall survival (OS). Cell growth, colony formation, and apoptotic assays were used to determine the biological functions of HDL on NPC cells in vitro. All of the statistical tests were two-sided. OS was decreased in patients with high pretreatment HDL-C levels compared with those with low HDL-C levels (P < 0.05). Similarly, a decreased OS was noted in advanced stage (stage III-IV), NPC patients with high pretreatment HDL-C levels (P < 0.01). Multivariate analyses indicated that HDL-C was an independent prognostic factor associated with shorter OS in training cohorts. These findings were confirmed in both independent validation cohorts (P < 0.01). In vitro experiments demonstrated that HDL could increase cell proliferation, invasion, and colony formation, which were largely dependent on the expression of its receptor SR-B1. Finally, HDL could enhance chemoresistance by protecting cancer cells from apoptosis. Pretreatment HDL-C is a poor prognostic factor for patients with NPC. This effect may be associated with the ability of HDL to enhance proliferation, colony formation, migration, and chemoresistance in NPC cells.
登录
查看更多内容
影响因子：
15.9
作者：
Besler, Christian;Heinrich, Kathrin;Landmesser, Ulf
通讯作者：
Landmesser, Ulf
鼻咽癌中 microRNA 特征的预后价值：microRNA 表达分析
影响因子：
51.1
作者：
Liu, Na;Chen, Nian-Yong;Ma, Jun
通讯作者：
Ma, Jun
DOI：
10.1038/nrgastro.2011.52
发表时间：
2011-06-01
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
Greenhill, Claire
通讯作者：
Greenhill, Claire
DOI：
10.4331/wjbc.v1.i11.327
发表时间：
2010-11-26
期刊：
World journal of biological chemistry
影响因子：
--
作者：
Sato, Koichi;Okajima, Fumikazu
通讯作者：
Okajima, Fumikazu
影响因子：
158.5
作者：
Lin, JC;Wang, WY;Jiang, RS
通讯作者：
Jiang, RS