Chronic helminth infections protect against allergic diseases by active regulatory processes.
Chronic helminth infections protect against allergic diseases by active regulatory processes.
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DOI：
10.1007/s11882-009-0085-3
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发表时间：
2010-01
影响因子：
5.5
通讯作者：
Yazdanbakhsh, Maria
中科院分区：
文献类型：
--
作者：
Smits, Hermelijn H.;Everts, Bart;Hartgers, Franca C.;Yazdanbakhsh, Maria
发达国家正在遭受免疫疾病的流行上升，例如与过敏相关的疾病和某些自身免疫。几项研究表明蠕虫感染与炎症性疾病(如过敏)之间存在负相关，这为蠕虫感染在这方面的参与提供了强有力的证据。然而，一些研究指出了相反的方向。这种差异可能是由于蠕虫的频率、剂量、时间和类型的不同造成的。在这篇综述中，讨论了一些新的研究，这些研究可能支持这样的概念，即慢性蠕虫感染--但不是急性感染--与调节对无害抗原的过敏免疫反应所必需的调控网络的表达有关。此外，还强调了调节网络的不同组成部分，如调节T和B细胞的作用，树突状细胞的调节，结构细胞(如上皮细胞)的早期先天信号，以及它们对预防过敏性疾病的个体贡献。定义和表征特定的蠕虫分子具有深刻的免疫调节能力，作为治疗应用于治疗或预防过敏表现的靶点是非常有意义的。
Developed countries are suffering from an epidemic rise in immunologic disorders, such as allergy-related diseases and certain autoimmunities. Several studies have demonstrated a negative association between helminth infections and inflammatory diseases (eg, allergy), providing a strong case for the involvement of helminth infections in this respect. However, some studies point in the opposite direction. The discrepancy may be explained by differences in frequency, dose, time, and type of helminth. In this review, new studies are discussed that may support the concept that chronic helminth infections in particular—but not acute infections—are associated with the expression of regulatory networks necessary for downmodulating allergic immune responses to harmless antigens. Furthermore, different components of regulatory networks are highlighted, such as the role of regulatory T and B cells, modulation of dendritic cells, early innate signals from structural cells (eg, epithelial cells), and their individual contributions to protection against allergic diseases. It is of great interest to define and characterize specific helminth molecules that have profound immunomodulatory capacities as targets for therapeutic application in the treatment or prophylaxis of allergic manifestations.
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DOI：
10.1038/nri2569
发表时间：
2009-07
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Geijtenbeek TB;Gringhuis SI
通讯作者：
Gringhuis SI
影响因子：
5.5
作者：
Elias, Daniel;Britton, Sven;Akuffo, Hannah
通讯作者：
Akuffo, Hannah
影响因子：
32.4
作者：
Barrett, Nora A.;Austen, K. Frank
通讯作者：
Austen, K. Frank
DOI：
10.1097/aci.0b013e32831f44a6
发表时间：
2009-02
影响因子：
2.8
作者：
Cooper PJ
通讯作者：
Cooper PJ
影响因子：
6.4
作者：
Hartgers, Franca C.;Obeng, Benedicta B.;Yazdanbakhsh, Maria
通讯作者：
Yazdanbakhsh, Maria