Establishment of tissue-resident immune populations in the fetus.
Establishment of tissue-resident immune populations in the fetus.
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DOI：
10.1007/s00281-022-00931-x
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发表时间：
2022-11
影响因子：
9
通讯作者：
Stelzer, Ina A.
中科院分区：
文献类型：
--
作者：
Feyaerts, Dorien;Urbschat, Christopher;Stelzer, Ina A.
免疫系统在产前时期由不同的干细胞和祖细胞波建立，并不断适应产后早期和成年生活的需求和挑战。胎儿免疫发育不仅为出生后免疫奠定了基础，而且建立了组织驻留免疫细胞的功能群，这些免疫细胞有助于器官生长和成熟过程中的胎儿免疫反应。本综述旨在讨论胎儿期组织驻留免疫群体的发育和功能的最新知识，重点关注大脑、肺和胃肠道这些具有不同发育轨迹的部位。虽然最近使用系统级方法取得的进展揭示了胎儿免疫状况，但仍需要进一步的工作来描述产前免疫群体的精确作用及其迁移和对各自器官环境的适应。确定产前对环境挑战的易感性点将支持寻找潜在的治疗靶点，以积极影响产后健康。
The immune system establishes during the prenatal period from distinct waves of stem and progenitor cells and continuously adapts to the needs and challenges of early postnatal and adult life. Fetal immune development not only lays the foundation for postnatal immunity but establishes functional populations of tissue-resident immune cells that are instrumental for fetal immune responses amidst organ growth and maturation. This review aims to discuss current knowledge about the development and function of tissue-resident immune populations during fetal life, focusing on the brain, lung, and gastrointestinal tract as sites with distinct developmental trajectories. While recent progress using system-level approaches has shed light on the fetal immune landscape, further work is required to describe precise roles of prenatal immune populations and their migration and adaptation to respective organ environments. Defining points of prenatal susceptibility to environmental challenges will support the search for potential therapeutic targets to positively impact postnatal health.
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DOI：
10.1186/s13223-018-0297-y
发表时间：
2018
期刊：
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
影响因子：
--
作者：
Singh AM;Sherenian MG;Kim KY;Erickson KA;Yang A;Mestan K;Ernst LM;Kumar R
通讯作者：
Kumar R
γ δ T 细胞会导致发育中的大脑损伤
DOI：
10.1016/j.ajpath.2017.11.012
发表时间：
2018-03
期刊：
The American journal of pathology
影响因子：
--
作者：
Albertsson AM;Zhang X;Vontell R;Bi D;Bronson RT;Supramaniam V;Baburamani AA;Hua S;Nazmi A;Cardell S;Zhu C;Cantor H;Mallard C;Hagberg H;Leavenworth JW;Wang X
通讯作者：
Wang X
影响因子：
2.5
作者：
Bulloch, Karen;Miller, Melinda M.;McEwen, Bruce S.
通讯作者：
McEwen, Bruce S.
影响因子：
5.3
作者：
Bilbo, SD;Biedenkapp, JC;Maier, SF
通讯作者：
Maier, SF
影响因子：
3
作者：
Bilbo SD;Schwarz JM
通讯作者：
Schwarz JM