Working memory training for adult glioma patients: a proof-of-concept study.
Working memory training for adult glioma patients: a proof-of-concept study.
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DOI：
10.1007/s11060-021-03839-y
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发表时间：
2021-10
影响因子：
3.9
通讯作者：
Loughan, Ashlee R.
中科院分区：
文献类型：
--
作者：
Braun, Sarah Ellen;Aslanzadeh, Farah J.;Lanoye, Autumn;Fountain-Zaragoza, Stephanie;Malkin, Mark G.;Loughan, Ashlee R.
认知工作记忆训练(CWMT)是一种基于计算机的程序，被证明可以改善认知障碍者的工作记忆(WM)。到目前为止，还没有研究调查它在成年胶质瘤患者中的可行性、可接受性和满意度，尽管在这一人群中有很好的证据表明WM损伤的发生率。20名有客观和/或感觉到的WM缺陷的胶质瘤患者参加了这项研究：52%的患者为高级别，60%为女性，MAGE=47(范围=21-72岁)。监测不良事件以确定安全性。根据已建立的指标评估了可行性和可接受性。满意度通过离职面谈来考察。在基线和CWMT后分析神经认知测试和心理症状，以估计效果大小。在入选的20名患者中，16名完成了干预(保留率为80%)。退出的原因包括时间负担(n=2)、肿瘤相关性疲劳(n=1)或失去随访(n=1)。没有不良事件被确定为与研究相关。坚持的比例为69%，不坚持的原因与退出研究的原因相似。人们感觉到的受益程度只是中等程度。CWMT后评估的基线显示对神经认知任务有中等到很大的影响。心理症状在整个研究期间保持稳定。CWMT在成年胶质瘤患者中被发现是安全和可接受的。登记、保留率和治疗依从性都是足够的，可以与招募相似人群的研究相媲美。尽管客观评估的WM表现出改善，但仅报告了适度的感知益处。这可能表明，时间承诺和干预强度(5周，每周5天，每次50分钟的培训课程)超过了该计划的预期好处。(试用注册号：NCT03323450，注册日期：2017年10月27日)。
CogMed Working Memory Training (CWMT) is a computer-based program shown to improve working memory (WM) among those with cognitive impairments. No study to date has investigated its feasibility, acceptability, and satisfaction in adult patients with glioma, despite the well-documented incidence of WM impairment in this population. Twenty patients with glioma and objective and/or perceived WM deficits enrolled in the study: 52% high-grade, 60% female, Mage = 47 (range = 21–72 years). Adverse events were monitored to determine safety. Feasibility and acceptability were assessed based on established metrics. Satisfaction was explored by exit-interviews. Neurocognitive tests and psychological symptoms were analyzed at baseline and post-CWMT to estimate effect sizes. Of 20 enrolled patients, 16 completed the intervention (80% retention rate). Reasons for withdrawal included time burden (n = 2); tumor-related fatigue (n = 1) or loss to follow-up (n = 1). No adverse events were determined to be study-related. Adherence was 69% with reasons for nonadherence similar to those for study withdrawal. The perceived degree of benefit was only moderate. Baseline to post-CWMT assessments showed medium to large effects on neurocognitive tasks. Psychological symptoms remained stable throughout the study period. CWMT was found to be safe and acceptable in adult patients with glioma. Enrollment, retention rates, and treatment adherence were all adequate and comparable to studies recruiting similar populations. Only moderate perceived benefit was reported despite demonstrated improvements in objectively-assessed WM. This may indicate that the time commitment and intervention intensity (5 weeks of 50-min training sessions on 5 days/week) outweighed the perceived benefits of the program. (Trial Registration Number: NCT03323450 registered on 10/27/2017).
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影响因子：
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作者：
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通讯作者：
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