Severe cervical dysplasia and nasal cartilage calcification following prenatal warfarin exposure.
Severe cervical dysplasia and nasal cartilage calcification following prenatal warfarin exposure.
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产前接触华法林后出现严重颈椎发育不良和鼻软骨钙化。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
W. Webster
中科院分区：
文献类型：
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作者：
A. M. Howe;A. Lipson;M. de Silva;R. Ouvrier;W. Webster
我们提出一个婴儿暴露于华法林在整个怀孕和华法林胚胎病。当孩子在20个月时进行影像学检查时，在鼻中隔和鼻翼软骨的小外部部分可见钙化区域。异位钙化的位置与华法林胚胎病的动物模型一致。它支持了华法林通过抑制维生素k依赖性蛋白的正常形成来干扰鼻中隔软骨的产前生长的假设，这种蛋白可以防止软骨钙化。这名儿童也有严重的颈椎畸形和脊髓继发性损伤。在华法林胚胎病和相关的宾德综合征中，颈椎异常是一个相对常见的发现。
We present an infant who was exposed to warfarin throughout pregnancy and has warfarin embryopathy. When the child was examined radiologically at 20 months areas of calcification were visible in the septal and alar cartilages of the small external part of the nose. The location of this ectopic calcification is consistent with that seen in an animal model of the warfarin embryopathy. It supports the hypothesis that warfarin interferes with the prenatal growth of the cartilaginous nasal septum by inhibiting the normal formation of a vitamin K-dependent protein that prevents calcification of cartilage. The child also had severe abnormalities of the cervical vertebrae and secondary damage to the spinal cord. Cervical vertebral anomalies are a relatively common finding in the warfarin embryopathy and in the related Binder syndrome.
DOI：
10.1016/s0021-9258(19)69522-0
发表时间：
1981-04
期刊：
The Journal of biological chemistry
影响因子：
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作者：
P. Price;J. W. Lothringer;S. Baukol;A. Reddi
通讯作者：
P. Price;J. W. Lothringer;S. Baukol;A. Reddi
大鼠钙化过程中基质 GLA 蛋白的发育表现。
DOI：
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发表时间：
1986
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Otawara,Y;Price,PA
通讯作者：
Price,PA
DOI：
10.1073/pnas.79.24.7734
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
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作者：
PRICE, PA;WILLIAMSON, MK;JEE, WSS
通讯作者：
JEE, WSS