Airborne endotoxin is associated with respiratory illness in the first 2 years of life.
Airborne endotoxin is associated with respiratory illness in the first 2 years of life.
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DOI：
10.1289/ehp.8142
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发表时间：
2006-04
影响因子：
10.4
通讯作者：
Judek S
中科院分区：
文献类型：
--
作者：
Dales R;Miller D;Ruest K;Guay M;Judek S
为了确定内毒素对2岁前急性呼吸道疾病发病率的影响，我们对加拿大爱德华王子岛出生的332名儿童进行了纵向随访研究，从出生开始。我们测量了儿童家中5天的平均空气内毒素水平，这些儿童的父母通过每日症状日记和每月两次电话联系提供信息，持续时间长达2年。内毒素浓度为0.49±3.49 EU/m3（几何平均±几何SD），年化发病次数为6.83±2.80次（平均±SD）。空气内毒素浓度增加一倍与每年0.32例疾病发作相关（p = 0.0003），调整了年龄、学习年份、母乳喂养、环境烟草烟雾、儿童保育出席率、室内温度和收入。室内霉菌表面积和真菌麦角甾醇与内毒素的关系不显著。空气中的内毒素似乎是生命最初2年临床症状性呼吸系统疾病的危险因素，独立于室内真菌。
To determine the influence of endotoxin on the incidence of acute respiratory illness during the first 2 years of life, we carried out a longitudinal follow-up study, beginning at birth, of 332 children born in Prince Edward Island, Canada. We measured 5-day averaged air endotoxin in the homes of children, whose parents provided information by daily symptom diaries and twice-monthly telephone contact for up to 2 years. Endotoxin concentration was 0.49 ± 3.49 EU/m3 (geometric mean ± geometric SD), and number of annualized illness episodes was 6.83 ± 2.80 (mean ± SD). A doubling of the air endotoxin concentration was associated with an increase of 0.32 illness episodes per year (p = 0.0003), adjusted for age, year of study, breast-feeding, environmental tobacco smoke, child care attendance, indoor temperature, and income. Indoor mold surface area and fungal ergosterol were not significantly associated with endotoxin. Airborne endotoxin appears to be a risk factor for clinically symptomatic respiratory illnesses during the first 2 years of life independent of indoor fungus.
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DOI：
10.1164/ajrccm.162.4.9909118
发表时间：
2000-10-01
影响因子：
24.7
作者：
Douwes, J;Zuidhof, A;Brunekreef, B
通讯作者：
Brunekreef, B
影响因子：
5.8
作者：
Foto, M;Vrijmoed, LLP;Dales, RE
通讯作者：
Dales, RE
影响因子：
14.2
作者：
Gehring, U;Bolte, G;Heinrich, J
通讯作者：
Heinrich, J
DOI：
10.1164/ajrccm.154.6.8970348
发表时间：
1996-12-01
影响因子：
24.7
作者：
Michel, O;Kips, J;Sergysels, R
通讯作者：
Sergysels, R
影响因子：
6.1
作者：
MICHEL, O;GINANNI, R;SERGYSELS, R
通讯作者：
SERGYSELS, R