On the relationship between tripartite motif-containing 22 single-nucleotide polymorphisms and COVID-19 infection severity.
On the relationship between tripartite motif-containing 22 single-nucleotide polymorphisms and COVID-19 infection severity.
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DOI：
10.1186/s40246-022-00394-z
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发表时间：
2022-08-26
期刊：
影响因子：
4.5
通讯作者：
Fateh, Abolfazl
中科院分区：
文献类型：
--
作者：
Raheem Juhi Al-Kaabi, Nidhal;Khameneh, Sepideh Chodari;Montazeri, Mohadeseh;Mardasi, Mahsa;Amroabadi, Jalal Mosayebi;Sakhaee, Fatemeh;Fateh, Abolfazl
关键词：
包含（TRIM）-22的三重基序参与先天免疫应答并表现出抗病毒活性。本研究旨在评估TRIM 22单核苷酸多态性和临床参数与2019冠状病毒病（COVID-19）感染严重程度之间的关系。 采用TaqMan聚合酶链反应（PCR）技术对495例死亡和497例SARS冠状病毒2型（SARS-CoV-2）阳性患者的TRIM 22基因多态性（rs7113258、rs7935564和rs 1063303）进行基因分型。 在这项研究中，TRIM 22 rs 1063303 GG、rs7935564 GG和rs7113258 TT的频率在死亡患者中显著高于改善患者，并且在死亡患者中观察到较高的病毒载量和较低的PCR Ct值。多因素Logistic回归分析显示，低密度脂蛋白（LDL）、胆固醇、PCR Ct值和25-羟维生素D水平较低，红细胞沉降率（ESR）、C反应蛋白（CRP）和TRIM 22 rs 1063303 GG、rs7113258 TT水平较高，rs3824949 GG基因型与COVID-19感染严重程度相关。 我们的发现证明了COVID-19感染严重程度与TRIM 22 SNPs基因型和临床参数之间的可能关系。需要在全球范围内进行更多研究，以显示COVID-19感染严重程度与宿主遗传因素之间的关联。
The tripartite motif containing (TRIM)-22 participates in innate immune responses and exhibits antiviral activities. The present study aimed to assess of the relationship between TRIM22 single-nucleotide polymorphisms and clinical parameters with the coronavirus disease 2019 (COVID-19) infection severity. TRIM22 polymorphisms (rs7113258, rs7935564, and rs1063303) were genotyped using TaqMan polymerase chain reaction (PCR) assay in 495 dead and 497 improved severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients. In this study, the frequencies of TRIM22 rs1063303 GG, rs7935564 GG, and rs7113258 TT were significantly higher in dead patients than in improved patients, and higher viral load with low PCR Ct value was noticed in dead patients. The multivariate logistic regression analysis revealed that the lower levels of low-density lipoprotein (LDL), cholesterol, PCR Ct value, and lower 25-hydroxyvitamin D, and also higher levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and TRIM22 rs1063303 GG, rs7113258 TT, and rs3824949 GG genotypes were related to the COVID-19 infection severity. Our finding proved the probable relationship between the COVID-19 infection severity with the genotypes of TRIM22 SNPs and clinical parameters. More research is required worldwide to show the association between the COVID-19 infection severity and host genetic factors.
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影响因子：
6.7
作者：
Barr SD;Smiley JR;Bushman FD
通讯作者：
Bushman FD
DOI：
10.1038/nri2413
发表时间：
2008-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Ozato K;Shin DM;Chang TH;Morse HC 3rd
通讯作者：
Morse HC 3rd
影响因子：
11.1
作者：
Velavan TP;Pallerla SR;Rüter J;Augustin Y;Kremsner PG;Krishna S;Meyer CG
通讯作者：
Meyer CG
影响因子：
5.7
作者：
Charman M;McFarlane S;Wojtus JK;Sloan E;Dewar R;Leeming G;Al-Saadi M;Hunter L;Carroll MW;Stewart JP;Digard P;Hutchinson E;Boutell C
通讯作者：
Boutell C
影响因子：
5.8
作者：
Sole, Xavier;Guino, Elisabet;Moreno, Vitor
通讯作者：
Moreno, Vitor