Convergent evolution in biosynthesis of cyanogenic defence compounds in plants and insects.
Convergent evolution in biosynthesis of cyanogenic defence compounds in plants and insects.
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DOI：
10.1038/ncomms1271
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发表时间：
2011
影响因子：
16.6
通讯作者：
Bak, Soren
中科院分区：
文献类型：
--
作者：
Jensen, Niels Bjerg;Zagrobelny, Mika;Hjerno, Karin;Olsen, Carl Erik;Houghton-Larsen, Jens;Borch, Jonas;Moller, Birger Lindberg;Bak, Soren
超过 4.2 亿年来，植物、昆虫及其捕食者在化学军备竞赛的基础上共同进化，其中包括每个参与者部署完善的化学防御系统。氰苷由多种植物和一些特殊昆虫产生，在这些密切的相互作用中作为防御化合物发挥着重要作用。地榆蛾幼虫能够从食用植物中螯合氰苷，并进行从头生物合成。在这里，我们发现三个基因（CYP405A2、CYP332A3 和 UGT33A1）编码地榆 Zygaena filipendulae 中氰苷的整个生物合成途径。在植物和昆虫中，趋同进化产生了两种多功能 P450 酶，每种酶都催化不寻常的反应，而一种葡萄糖基转移酶则依次催化氰苷的形成。因此，植物和昆虫独立地找到了一种包装氰化物定时炸弹来抵御食草动物和捕食者的方法。 植物和动物中释放氰化物的防御系统对于植物与草食动物相互作用的进化非常重要。作者确定了六斑地榆毛虫负责生物合成氰苷的酶，这些酶是独立于已知的植物途径进化的。
For more than 420 million years, plants, insects and their predators have co-evolved based on a chemical arms race including deployment of refined chemical defence systems by each player. Cyanogenic glucosides are produced by numerous plants and by some specialized insects and serve an important role as defence compounds in these intimate interactions. Burnet moth larvae are able to sequester cyanogenic glucosides from their food plant as well as to carry out de novo biosynthesis. Here we show that three genes (CYP405A2, CYP332A3 and UGT33A1) encode the entire biosynthetic pathway of cyanogenic glucosides in the Burnet moth Zygaena filipendulae. In both plants and insects, convergent evolution has led to two multifunctional P450 enzymes each catalysing unusual reactions and a glucosyl-transferase acting in sequence to catalyse cyanogenic glucoside formation. Thus, plants and insects have independently found a way to package a cyanide time bomb to fend off herbivores and predators. Cyanide-releasing defence systems in plants and animals are important to the evolution of plant–herbivore interactions. The authors identify the enzymes responsible for biosynthesis of cyanogenic glucosides by Six-spot Burnet moth caterpillars, which have evolved independently from the known plant pathway.
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影响因子：
14.8
作者：
通讯作者：
--
影响因子：
5.8
作者：
Larkin, M. A.;Blackshields, G.;Higgins, D. G.
通讯作者：
Higgins, D. G.
影响因子：
3.8
作者：
Paquette, S;Moller, BL;Bak, S
通讯作者：
Bak, S
影响因子：
2.6
作者：
FRANZL, S;NAUMANN, CM
通讯作者：
NAUMANN, CM
DOI：
10.1016/0020-1790(87)90037-0
发表时间：
1987-01-01
期刊：
INSECT BIOCHEMISTRY
影响因子：
--
作者：
DAVIS, RH;NAHRSTEDT, A
通讯作者：
NAHRSTEDT, A