Gene therapy access: Global challenges, opportunities, and views from Brazil, South Africa, and India.
Gene therapy access: Global challenges, opportunities, and views from Brazil, South Africa, and India.
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DOI：
10.1016/j.ymthe.2022.04.002
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发表时间：
2022-06-01
影响因子：
12.4
通讯作者：
Rao, Jayandharan
中科院分区：
文献类型：
--
作者：
Cornetta, Kenneth;Bonamino, Martin;Mahlangu, Johnny;Mingozzi, Federico;Rangarajan, Savita;Rao, Jayandharan
针对多种危及生命的疾病的基因和细胞疗法正在研究中，少数商业产品已成功获得监管部门的批准。治疗费用高，评估安全性和有效性的临床研究主要在高收入国家进行。我们回顾了低收入和中等收入国家基因和细胞疗法的现状，并强调了获得这些疗法的必要性和目前的障碍。讨论了巴西、南非和印度的产品开发状况，包括从美国基因与细胞治疗学会（ASGCT）在这些国家主办的虚拟研讨会中吸取的经验教训。
Gene and cell therapies for a variety of life-limiting illnesses are under investigation, and a small number of commercial products have successfully obtained regulatory approval. The cost of treatment is high, and clinical studies evaluating safety and efficacy are performed predominately in high-income countries. We reviewed the current status of gene and cell therapies in low- and middle-income countries and highlighted the need and current barriers to access. The state of product development in Brazil, South Africa, and India is discussed, including lessons learned from American Society of Gene and Cell Therapy (ASGCT)-sponsored virtual symposia in each of these countries.
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影响因子：
2.2
作者：
Ely, A.;Bloom, K.;Arbuthnot, P.
通讯作者：
Arbuthnot, P.
影响因子：
4.1
作者：
Cochrane, J
通讯作者：
Cochrane, J
影响因子：
3.7
作者：
Jayasundara, Kavisha;Hollis, Aidan;Grootendorst, Paul
通讯作者：
Grootendorst, Paul
影响因子：
6.4
作者：
McKenzie, Fiona;Zietsman, Annelle;McCormack, Valerie
通讯作者：
McCormack, Valerie
影响因子：
--
作者：
Grover S;Martei YM;Puri P;Prabhakar P;Mutebi M;Balogun OD;Price AJ;Freeman AH;Narasimhamurthy M;Rodin D;Rayne S;Zetola NM
通讯作者：
Zetola NM