Time course and cellular characteristics of the iliac artery response to acute balloon injury. An angiographic, morphometric, and immunocytochemical analysis in the cholesterol-fed New Zealand white rabbit.
Time course and cellular characteristics of the iliac artery response to acute balloon injury. An angiographic, morphometric, and immunocytochemical analysis in the cholesterol-fed New Zealand white rabbit.
复制标题
髂动脉对急性球囊损伤反应的时间过程和细胞特征。
DOI：
10.1161/01.atv.12.11.1267
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Allen M. Gown
中科院分区：
文献类型：
--
作者：
M. Stadius;Reed Rowan;J. Fleischhauer;Robert S. Kernoff;M. Billingham;Allen M. Gown
随着血管成形术治疗人类动脉粥样硬化病变的兴趣与日俱增，在实验模型中评价动脉血管壁对急性动脉损伤的反应具有重要意义。本研究在24只喂饲2%胆固醇饲料的新西兰大白兔的45个髂动脉节段上，研究了正常动脉对急性球囊损伤的反应。在球囊回缩损伤后1至41天的特定时间点，采用血管造影、形态计量学和免疫细胞化学技术对髂动脉进行分析。血管造影测量显示，随着损伤持续时间的延长，髂动脉管腔逐渐受损。形态计量学测量显示内膜面积由伤后3d的0.004±0.01mm2增加到伤后34~41d的1.15士/-0.30mm2。细胞系特异性免疫细胞化学分析证实巨噬细胞是最早的内膜细胞浸润性病变的主要成分。损伤后7~9d，内膜内可见平滑肌细胞。随着内膜面积的增大，内膜损伤的内弹力层以巨噬细胞为主，而血管内膜邻近管腔的部分以平滑肌细胞为主。综上所述，逆行球囊回缩损伤后胆固醇摄入导致动脉腔内逐渐狭窄，这是由于动脉内膜细胞浸润逐渐扩大。在发育中的内膜细胞浸润物中，平滑肌细胞和巨噬细胞成分在时间和空间上的作用已经被表征。
Evaluation of the response of the arterial vessel wall to acute arterial injury in experimental models has taken on substantial importance because of an increasing interest in angioplasty treatment of human atherosclerotic lesions. In this study, the response of normal arterial vessels to acute balloon injury was studied in 45 iliac artery segments from 24 New Zealand White rabbits fed a 2% cholesterol diet. At specified time points between 1 and 41 days after the initial balloon pullback injury, the iliac arteries were analyzed by angiographic, morphometric, and immunocytochemical techniques. Angiographic measurements indicated progressive compromise of the iliac artery lumen with increasing duration of time from injury. Morphometric measurements showed that intimal area increased from 0.004 +/- 0.01 mm2 3 days after injury to 1.15 +/- 0.30 mm2 34-41 days after injury. Cell line-specific immunocytochemical analysis identified the macrophage as a prominent component of the earliest intimal cellular infiltrate. Smooth muscle cells appeared within the intima 7-9 days after injury. As the intima increased in area, macrophages predominated along the internal elastic lamina aspect of the intimal lesion while smooth muscle cells occupied the portion of the intima adjacent to the lumen. In summary, retrograde balloon pullback injury followed by cholesterol feeding results in progressive arterial luminal narrowing due to a progressively enlarging intimal cellular infiltrate. The temporal and spatial contributions of smooth muscle cell and macrophage components of the developing intimal cellular infiltrate have been characterized.
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影响因子：
15.9
作者：
ROSENFELD, ME;KHOO, JC;WITZTUM, JL
通讯作者：
WITZTUM, JL
DOI：
--
发表时间：
1989-03
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
A. Clowes;Clowes Mm;J. Fingerle;M. Reidy
通讯作者：
A. Clowes;Clowes Mm;J. Fingerle;M. Reidy
DOI：
10.1161/01.atv.6.6.601
发表时间：
1986-11-01
期刊：
ARTERIOSCLEROSIS
影响因子：
--
作者：
TSUKADA, T;ROSENFELD, M;GOWN, AM
通讯作者：
GOWN, AM
实验性动脉粥样硬化中准分子与热激光血管成形术的急性生物反应。
影响因子：
24
作者：
Marmur,JD;Sanborn,TA;Kahn,H;Badimon,JJ;Badimon,L;Fuster,V
通讯作者：
Fuster,V
用光感受器间视黄醇结合蛋白免疫后兔子的葡萄膜视网膜炎。
影响因子：
3.4
作者：
Eisenfeld,AJ;Bunt-Milam,AH;Saari,JC
通讯作者：
Saari,JC