Phenolic-rich extract from the Costa Rican guava (Psidium friedrichsthalianum) pulp with antioxidant and anti-inflammatory activity. Potential for COPD therapy.
Phenolic-rich extract from the Costa Rican guava (Psidium friedrichsthalianum) pulp with antioxidant and anti-inflammatory activity. Potential for COPD therapy.
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DOI：
10.1016/j.foodchem.2013.03.025
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发表时间：
2013-11-15
期刊：
影响因子：
8.8
通讯作者：
Kennelly, Edward J.
中科院分区：
文献类型：
--
作者：
Flores, Gema;Dastmalchi, Keyvan;Wu, Shi-Biao;Whalen, Kathleen;Dabo, Abdoulaye J.;Reynertson, Kurt A.;Foronjy, Robert F.;D'Armiento, Jeanine M.;Kennelly, Edward J.
关键词：
哥斯达黎加番石榴（Psidium friedrichsthalianum）提取物对慢性阻塞性肺疾病的潜在治疗作用进行了检查。乙酸乙酯馏分表现出最高的抗氧化活性，相比，己烷，氯仿，正丁醇馏分，以及粗提物。在用香烟烟雾处理之前和之后，评价该组分对白细胞介素-8（IL-8）的抗炎活性反应关系和对基质金属蛋白酶-1（MMP-1）表达的抑制。乙酸乙酯部分显示出对IL-8产生和MMP-1表达的抑制活性，在100 μg/mL的两种测定中显示出最有效的抑制活性，并且发现了9种化合物（1-9），酚类化合物1-O-反式-肉桂酰基-β-D-吡喃葡萄糖（2），鞣花酸（3），杨梅苷（4），槲皮苷（7），和槲皮素（9）的鉴定使用标准化合物或文献报道从相关物种。化合物1、5、6和8分别鉴定为柠檬酸二甲酯（1）、芥子醛4-O-β-D-吡喃葡萄糖（5）、3，3 ′，4-三-O-甲基鞣花酸-4 ′-O-D-吡喃葡萄糖苷（6）和1，3-O-二阿魏酰甘油（8）。
The potential therapeutic effects of Costa Rican guava (Psidium friedrichsthalianum) extracts for chronic obstructive pulmonary disease were examined. The ethyl acetate fraction displayed the highest antioxidant activity, as compared to the hexane, chloroform, and n-butanol fractions, as well as the crude extract. This fraction was evaluated for its anti-inflammatory activity response relationship against interleukin-8 (IL-8) and inhibition of matrix metalloproteinase-1 (MMP-1) expression before and after treatment with cigarette smoke. The ethyl acetate fraction exhibited inhibitory activity against IL-8 production and MMP-1 expression, showing the most potent inhibitory activities in both assays at 100 μg/mL, and nine compounds (1–9) were found. Phenolic compounds 1-O-trans-cinnamoyl-β-D-glucopyranose (2), ellagic acid (3), myricetin (4), quercitrin (7), and quercetin (9) were identified using standard compounds or literature reports from related species. Compounds 1, 5, 6, and 8 were tentatively identified as 1,5-dimethyl citrate (1), sinapic aldehyde 4-O-β-D-glucopyranose (5), 3,3′,4-tri-O-methylellagic acid-4′-O-D-glucopyranoside (6), and 1,3-O-diferuloylglycerol (8), All nine compounds are reported for the first time in Costa Rican guava.
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影响因子：
6.1
作者：
Dastmalchi K;Flores G;Petrova V;Pedraza-Peñalosa P;Kennelly EJ
通讯作者：
Kennelly EJ
影响因子：
6.1
作者：
Mahattanatawee, Kanjana;Manthey, John A.;Baldwin, Elizabeth A.
通讯作者：
Baldwin, Elizabeth A.
影响因子：
7.1
作者：
Arts, ICW;Hollman, PCH
通讯作者：
Hollman, PCH
影响因子：
10.4
作者：
CROSS, CE;VANDERVLIET, A;HALLIWELL, B
通讯作者：
HALLIWELL, B
影响因子：
--
作者：
Haq I;Chappell S;Johnson SR;Lotya J;Daly L;Morgan K;Guetta-Baranes T;Roca J;Rabinovich R;Millar AB;Donnelly SC;Keatings V;MacNee W;Stolk J;Hiemstra PS;Miniati M;Monti S;O'Connor CM;Kalsheker N
通讯作者：
Kalsheker N