Screening for cancer with molecular markers: progress comes with potential problems.

Screening for cancer with molecular markers: progress comes with potential problems.
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DOI:
10.1038/nrc3260
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发表时间:
2012-04-12
期刊:
Nature reviews. Cancer
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其他
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最近的研究给人们带来了希望,即利用分子生物标志物进行极其准确的癌症筛查。这些分子标记可能比旧的筛查方式更灵敏、更特异,也更易于使用。在这篇观点文章中,我认为这些敏感的筛查测试可能具有临床价值,但在实施和解释方面会带来独特的问题。这些可能会影响临床医生进行筛查的方式以及对筛查呈阳性的个体进行诊断的方式。
Recent research has raised hopes for impressively accurate screening for cancer with molecular biomarkers. These molecular markers will probably be more sensitive and specific than older screening modalities, as well easier to use. In this Perspective article, I argue that these sensitive screening tests may be clinically valuable – but will present unique issues in implementation and interpretation. These are likely to affect the way clinicians conduct screening and the way they make diagnoses in individuals who screen positive.
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