Drug Loading in Poly(butyl cyanoacrylate)-Based Polymeric Microbubbles.
Drug Loading in Poly(butyl cyanoacrylate)-Based Polymeric Microbubbles.
复制标题
DOI：
10.1021/acs.molpharmaceut.0c00242
复制
发表时间：
2020-08-03
影响因子：
4.9
通讯作者：
Lammers T
中科院分区：
文献类型：
--
作者：
Liu M;Dasgupta A;Koczera P;Schipper S;Rommel D;Shi Y;Kiessling F;Lammers T
微泡（MB）是常规使用的超声造影剂，最近作为刺激反应性药物传递系统引起了越来越多的关注。为了更好地了解基于MB的药物传递，我们研究了药物疏水性和分子量对MB负载、保质期稳定性、US性质和药物释放的影响。8种不同疏水性和分子量的模型药物被装载到聚氰丙烯酸丁酯（PBCA） MB的外壳中。以黄体酮为共同结构骨架的药物（如皮质类固醇）的装载能力和药物释放与疏水性和分子量有良好的相关性。相反，当使用没有结构相似性的药物（即四种不同的荧光染料）时，负载能力和释放与疏水性和分子量无关。所有模型载药MB制剂在暴露于US后都能同样有效地破坏。总之，这些发现为（模型）药物分子的物理化学性质如何影响其在聚合物MB中的装载和保留以及us诱导的释放提供了有价值的见解，从而促进了用于us触发药物递送的载药MB配方的开发。
Microbubbles (MB) are routinely used ultrasound (US) contrast agents that have recently attracted increasing attention as stimuli-responsive drug delivery systems. In order to better understand MB-based drug delivery, we studied the role of drug hydrophobicity and molecular weight on MB loading, shelf-life stability, US properties and drug release. Eight model drugs, varying in hydrophobicity and molecular weight, were loaded into the shell of poly(butyl cyanoacrylate) (PBCA) MB. In the case of drugs with progesterone as a common structural backbone (i.e. for corticosteroids), loading capacity and drug release correlated well with hydrophobicity and molecular weight. Conversely, when employing drugs with no structural similarity (i.e. four different fluorescent dyes), loading capacity and release did not correlate with hydrophobicity and molecular weight. All model drug-loaded MB formulations could be equally efficiently destroyed upon exposure to US. Together, these findings provide valuable insights on how the physicochemical properties of (model) drug molecules affect their loading and retention in and US-induced release from polymeric MB, thereby facilitating the development of drug-loaded MB formulations for US-triggered drug delivery.
登录
查看更多内容
DOI：
10.1179/175889709x446507
发表时间：
2009-11
期刊：
Bubble science engineering and technology
影响因子：
--
作者：
Sirsi S;Borden M
通讯作者：
Borden M
影响因子：
10.8
作者：
Koczera, Patrick;Appold, Lia;Lammers, Twan
通讯作者：
Lammers, Twan
影响因子：
6.4
作者：
Treat, Lisa H.;McDannold, Nathan;Hynynen, Kullervo
通讯作者：
Hynynen, Kullervo
影响因子：
4.9
作者：
Liu, Zhe;Koczera, Patrick;Gaetjens, Jessica
通讯作者：
Gaetjens, Jessica
罗丹明B多官能团在复合材料表面的表面结合及其高性能光降解
影响因子：
6.7
作者：
Wan, Yiqun;Wang, Xiaofen;Xu, Zhaodi
通讯作者：
Xu, Zhaodi