Down-regulated miR-22 as predictive biomarkers for prognosis of epithelial ovarian cancer.
Down-regulated miR-22 as predictive biomarkers for prognosis of epithelial ovarian cancer.
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DOI：
10.1186/s13000-014-0178-8
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发表时间：
2014-09-26
影响因子：
2.6
通讯作者：
Li P
中科院分区：
文献类型：
--
作者：
Wan WN;Zhang YQ;Wang XM;Liu YJ;Zhang YX;Que YH;Zhao WJ;Li P
最近的研究表明，microRNA-22 （miR-22）在许多类型的癌症中被解除调控，并参与与癌变有关的各种细胞过程。然而，miR-22在上皮性卵巢癌（EOC）中的临床意义和预后价值尚未得到研究。2007年5月至2013年3月共采集了109对新鲜EOC组织和匹配的邻近正常组织标本。采用实时定量RT-PCR检测miR-22的表达水平。采用卡方检验评估miR-22的表达与临床病理参数的关系。采用Kaplan-Meier法和Cox回归测定患者的生存曲线，采用log-rank检验进行统计学评价。miR-22在EOC组织中的表达明显低于匹配的正常邻近组织（mean±SD: 1.944±1.026 vs. 4.981±1.507,P < 0.0001）。miR-22低表达水平与FIGO分期（P = 0.006）、肿瘤分级（P = 0.03）、淋巴结转移（P = 0.01）相关。Kaplan-Meier分析和log-rank检验显示，miR-22低表达对总生存率（44.4%比64.5%,P = 0.005）和无进展生存率（23.5%比52.6%,P = 0.004）有显著影响。我们的数据表明，miR-22的表达在EOC中下调，并且与总生存期和无进展生存期相关，这表明miR-22可以作为EOC患者的有效预后因素。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_178
Recent studies have demonstrated that microRNA-22 (miR-22) was deregulated in many types of cancers and was involved in various cellular processes related to carcinogenesis. However, the clinical significance and prognostic value of miR-22 in epithelial ovarian cancer (EOC) haven’t been investigated. 109 pairs of fresh EOC tissue and matched adjacent normal tissue specimens were collected between May 2007 and March 2013. Real-time quantitative RT-PCR assay was performed to evaluate the expression levels of miR-22. The chi-square test was used to assess miR-22 expression with respect to clinicopathological parameters. The survival curves of the patients were determined using the Kaplan-Meier method and Cox regression, and the log-rank test was used for statistical evaluations. miR-22 expression in EOC tissues was significantly lower than that in matched normal adjacent tissues (mean ± SD: 1.944 ± 1.026 vs. 4.981 ± 1.507, P < 0.0001). Low miR-22 expression level was correlated with FIGO stage (P = 0.006), tumor grade (P = 0.03), and lymph node metastases (P = 0.01). Kaplan-Meier analysis with the log-rank test indicated that low miR-22 expression had a significant impact on overall survival (44.4% vs. 64.5%; P = 0.005) and progression-free survival (23.5% vs. 52.6%; P = 0.004). Our data demonstrated that the expression of miR-22 was downregulated in EOC, and associated with overall survival as well as progression-free survival, suggesting that miR-22 could serve as an efficient prognostic factor for EOC patients. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_178
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影响因子：
37.8
作者：
Gurha P;Abreu-Goodger C;Wang T;Ramirez MO;Drumond AL;van Dongen S;Chen Y;Bartonicek N;Enright AJ;Lee B;Kelm RJ Jr;Reddy AK;Taffet GE;Bradley A;Wehrens XH;Entman ML;Rodriguez A
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影响因子：
2.6
作者：
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