The efficacy and safety of topical tranexamic acid (liposomal or lotion with microneedling) versus conventional hydroquinone in the treatment of melasma
The efficacy and safety of topical tranexamic acid (liposomal or lotion with microneedling) versus conventional hydroquinone in the treatment of melasma
复制标题
外用氨甲环酸（脂质体或微针洗剂）与传统对苯二酚治疗黄褐斑的疗效和安全性
DOI：
10.1111/jocd.13810
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发表时间：
2020-10
影响因子：
2.3
通讯作者：
Xiang Leihong
中科院分区：
文献类型：
--
作者：
Xing Xiaoxue;Chen Li;Xu Zhongyi;Jin Shanglin;Zhang Chengfeng;Xiang Leihong
研究背景目前尚无关于外用氨甲环酸（TA）治疗黄褐斑有效性的有力证据。目的评价1.8% TA脂质体与5% TA溶液微针治疗黄褐斑的疗效和安全性。方法将60例黄褐斑患者随机分为3组：1. 8% TA脂质体治疗组，2次/d; 5% TA微针治疗组，2%氢醌微针治疗组，1次/d。在基线、第4、8和12周获得客观和主观评估。结果TA脂质体组、微针加TA溶液组和氢醌组患者的“改善50%以上”率分别为27.8%、33.3%和30.0%。“在终点时，所有治疗组的黑色素指数（MI）均显著降低，而微针TA溶液组和氢醌组的MI改善程度高于脂质体TA组。TA脂质体组和TA溶液微针组的红斑指数（EI）显著降低。皮肤镜检查和反射共聚焦显微镜显示所有组中棕色颗粒减少，脂质体TA组和微针TA溶液组中毛细血管扩张减少。结论1.8% TA脂质体和5% TA溶液微针治疗黄褐斑均安全有效。
Background Robust evidence regarding the efficacy of topical tranexamic acid (TA) on melasma in Chinese population is lacking. Objective To evaluate the efficacy and safety of 1.8% liposomal TA and microneedling with 5% TA solution on melasma. Methods Sixty melasma patients were enrolled and randomized to receive 1.8% liposomal TA twice daily, microneedling with 5% TA solution weekly or 2% hydroquinone every night. Objective and subjective assessments were obtained at baseline, 4, 8, and 12 weeks. Results 27.8% of patients of liposomal TA group, 33.3% of microneedling with TA solution group, and 30.0% of hydroquinone group were recognized as "more than 50% improvement." At the endpoint, the melanin index (MI) in all treatment groups was significantly decreased, while the improvement of MI in microneedling with TA solution group and hydroquinone group is higher than liposomal TA group. The erythema index (EI) was significantly diminished in liposomal TA group and microneedling with TA solution group. Dermatoscopy and reflectance confocal microscopy revealed decreased brown granules in all groups and reduced telangiectasia in liposomal TA group and microneedling with TA solution group. Conclusion 1.8% liposomal TA and microneedling with 5% TA solution are both effective and safe on melasma.
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影响因子：
2.3
作者：
Izquierdo, Maria Cecilia;Lillo, Cristian R.;Montanari, Jorge
通讯作者：
Montanari, Jorge
影响因子：
13.8
作者：
Lee, Hwee Chyen;Thng, Tien Guan Steven;Goh, Chee Leok
通讯作者：
Goh, Chee Leok
DOI：
10.1111/j.1468-3083.2012.04464.x
发表时间：
2013-08-01
影响因子：
9.2
作者：
Na, J. I.;Choi, S. Y.;Park, K. -C.
通讯作者：
Park, K. -C.
影响因子：
2.3
作者：
Banihashemi, Mahnaz;Zabolinejad, Naghmeh;Jabari, Asma
通讯作者：
Jabari, Asma
影响因子：
2.3
作者：
Huijuan Zhao;Mengna Li;Xiaofeng Zhang;Li Li-Li;Yan Yan-Yan;Baoxi Wang
通讯作者：
Huijuan Zhao;Mengna Li;Xiaofeng Zhang;Li Li-Li;Yan Yan-Yan;Baoxi Wang