Low tryptophan levels are associated with postoperative delirium in the elderly.
Low tryptophan levels are associated with postoperative delirium in the elderly.
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DOI：
10.1016/j.amjsurg.2008.07.007
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发表时间：
2008-11
影响因子：
3
通讯作者：
Moss, Marc
中科院分区：
文献类型：
--
作者：
Robinson, Thomas N.;Raeburn, Christopher D.;Angles, Erik M.;Moss, Marc
术后谵妄是老年患者的常见并发症。色氨酸是稳定情绪的神经递质血清素和褪黑素的一种氨基酸前体。我们假设色氨酸水平较低的老年受试者发生术后谵妄。进行了一项前瞻性观察研究。年龄大于50岁的患者接受手术，预计术后将入住ICU。术后谵妄评估每日使用神志不清评估法- icu。术后2天检测外周血血清色氨酸水平。纳入49例受试者，其中男性46例，年龄64±7岁。谵妄发生率为43%（21/49）。谵妄持续时间平均为2.9±3.0 d。色氨酸在发生谵妄的受试者中较低（29.9±13.3 vs 48.5±19.8µg/ml, *p<0.001）。老年患者术后色氨酸水平较低与谵妄的发生有关。
Post-operative delirium is a common complication in geriatric patients. Tryptophan is an amino acid precursor to the mood stabilizing neurotransmitters serotonin and melatonin. We hypothesized that tryptophan levels are lower in elderly subjects who develop post-operative delirium. A prospective observational study was performed. Subjects older than 50 years undergoing an operation with an anticipated post-operative ICU admission were recruited. Post-operative delirium assessment occurred daily using the Confusion Assessment Method-ICU. Peripheral serum tryptophan levels were measured two days following surgery. Forty-nine subjects (46 male) were enrolled with an age of 64±7 years. The incidence of delirium was 43% (21/49). The average duration of delirium was 2.9±3.0 days. Tryptophan was lower in the subjects who developed delirium (29.9±13.3 versus 48.5±19.8 µg/ml, *p<0.001) Lower levels of tryptophan post-operatively were associated with the development of delirium in the elderly.
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影响因子：
8.8
作者：
Ely, EW;Margolin, R;Inouye, SK
通讯作者：
Inouye, SK
DOI：
10.1046/j.1532-5415.2003.51465.x
发表时间：
2003-10-01
影响因子：
6.3
作者：
Borson, S;Scanlan, JM;Ganguli, M
通讯作者：
Ganguli, M
影响因子：
3.4
作者：
Murphy, Susannah E.;Longhitano, Calogero;Harmer, Catherine J.
通讯作者：
Harmer, Catherine J.
影响因子：
4.7
作者：
Uchida, K;Aoki, T;Ishizuka, B
通讯作者：
Ishizuka, B
影响因子：
120.7
作者：
MARCANTONIO, ER;GOLDMAN, L;LEE, TH
通讯作者：
LEE, TH