pH-responsive theranostic nanocomposites as synergistically enhancing positive and negative magnetic resonance imaging contrast agents.
pH-responsive theranostic nanocomposites as synergistically enhancing positive and negative magnetic resonance imaging contrast agents.
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pH响应性治疗诊断纳米复合材料作为协同增强正负磁共振成像造影剂
DOI：
10.1186/s12951-018-0350-5
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发表时间：
2018-03-27
影响因子：
10.2
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Huang X;Yuan Y;Ruan W;Liu L;Liu M;Chen S;Zhou X
疗法纳米探针的合理设计对肿瘤环境中的治疗效力和增强诊断成像的反应效果的合理设计对于有效的个性化癌症治疗和其他生物医学应用起着至关重要的作用。我们的目的是提供一种潜在的策略来构成T1-加权MRI功能，从而实现成像引导的药物输送和有针对性的治疗。
疗法纳米复合材料Mn-Porphyrin＆fe3O4@sio2@paa-crgd被制造并表征，纳米复合材料有效地用于T1-和T2加权MRI和PH响应性药物释放中。荧光成像还表明，通过受体介导的过程在肺癌细胞中特别积累的纳米复合材料，对正常细胞无毒。中性pH 7.4中的R2/R1比为20.6，在酸性pH 5.0中降至7.7，表明NC可以在肿瘤酸性环境下充当理想的T1/T2双模式对比剂。对于体内MRI，在静脉注射后，在肿瘤中，T1和T2松弛分别显着加速至55％和37％。注射纳米复合材料。
合成的纳米复合材料通过协同增强正磁共振成像信号在溶液，细胞或体内表现出高度敏感的MRI对比功能。纳米复合材料在将影像学诊断和药物控制释放中纳入一个组合物中显示出很大的潜力，并在目标治疗过程中以极大的诊断精度提供了实时成像。
本文的在线版本（10.1186/S12951-018-0350-5）包含补充材料，可供授权用户使用。
BackgroundThe rational design of theranostic nanoprobe to present responsive effect of therapeutic potency and enhanced diagnostic imaging in tumor milieu plays a vital role for efficient personalized cancer therapy and other biomedical applications. We aimed to afford a potential strategy to pose both T1- and T2-weighted MRI functions, and thereby realizing imaging guided drug delivery and targeted therapy.ResultsTheranostic nanocomposites Mn-porphyrin&Fe3O4@SiO2@PAA-cRGD were fabricated and characterized, and the nanocomposites were effectively used in T1- and T2-weighted MRI and pH-responsive drug release. Fluorescent imaging also showed that the nanocomposites specifically accumulated in lung cancer cells by a receptor-mediated process, and were nontoxic to normal cells. The r2/r1ratio was 20.6 in neutral pH 7.4, which decreased to 7.7 in acidic pH 5.0, suggesting the NCs could act as an ideal T1/T2dual-mode contrast agent at acidic environments of tumor. For in vivo MRI, T1and T2relaxation was significantly accelerated to 55 and 37%, respectively, in the tumor after i.v. injection of nanocomposites.ConclusionThe synthesized nanocomposites exhibited highly sensitive MRI contrast function no matter in solution, cells or in vivo by synergistically enhancing positive and negative magnetic resonance imaging signals. The nanocomposites showed great potential for integrating imaging diagnosis and drug controlled release into one composition and providing real-time imaging with greatly enhanced diagnostic accuracy during targeted therapy.
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影响因子：
3.5
作者：
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通讯作者：
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作者：
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