The Impact of Maternal Body Composition and Dietary Fat Consumption upon Placental Lipid Processing and Offspring Metabolic Health.
The Impact of Maternal Body Composition and Dietary Fat Consumption upon Placental Lipid Processing and Offspring Metabolic Health.
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DOI：
10.3390/nu12103031
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发表时间：
2020-10-03
期刊：
影响因子：
5.9
通讯作者：
Regnault TRH
中科院分区：
文献类型：
--
作者：
Easton ZJW;Regnault TRH
全球育龄妇女超重或肥胖的比例正在增加。在人类研究和动物模型中，肥胖与暴露后代中成人相关代谢疾病（包括代谢综合征）的早发性发展密切相关。然而，动物模型研究表明，肥胖孕妇的妊娠期饮食是后代日后代谢疾病风险的独立但未得到充分重视的媒介，人类饮食消费数据强调，许多妇女在怀孕前和怀孕期间不遵守营养指南。因此，本次审查将强调母亲的饮食独立于母体的身体成分如何影响肥胖暴露后代的晚年代谢疾病的风险。不良的母体饮食，结合肥胖的代谢状态，被理解为促进病理性子宫内编程，特别是通过胎盘绒毛滋养层中脂质处理过程的变化，其促进与后代中代谢疾病的发展相关的环境。这篇综述还将强调母体肥胖如何调节绒毛滋养层脂质加工功能，包括脂肪酸转运，酯化和β-氧化。此外，这篇综述将讨论如何改变母亲妊娠饮食可能会改善这些功能的变化，在肥胖胎盘的脂质代谢过程。
The proportion of women of reproductive age who are overweight or obese is increasing globally. Gestational obesity is strongly associated in both human studies and animal models with early-onset development of adult-associated metabolic diseases including metabolic syndrome in the exposed offspring. However, animal model studies have suggested that gestational diet in obese pregnancies is an independent but underappreciated mediator of offspring risk for later life metabolic disease, and human diet consumption data have highlighted that many women do not follow nutritional guidelines prior to and during pregnancy. Thus, this review will highlight how maternal diet independent from maternal body composition impacts the risk for later-life metabolic disease in obesity-exposed offspring. A poor maternal diet, in combination with the obese metabolic state, are understood to facilitate pathological in utero programming, specifically through changes in lipid handling processes in the villous trophoblast layer of the placenta that promote an environment associated with the development of metabolic disease in the offspring. This review will additionally highlight how maternal obesity modulates villous trophoblast lipid processing functions including fatty acid transport, esterification and beta-oxidation. Further, this review will discuss how altering maternal gestational diet may ameliorate these functional changes in lipid metabolic processes in the obese placenta.
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影响因子：
3.8
作者：
Alvarado, Fernanda L.;Calabuig-Navarro, Virtu;O'Tierney-Ginn, Perrie
通讯作者：
O'Tierney-Ginn, Perrie
影响因子：
8
作者：
Boney, CM;Verma, A;Vohr, BR
通讯作者：
Vohr, BR
DOI：
10.1590/s0034-89102008000100002
发表时间：
2008-02-01
期刊：
Revista de Saúde Pública
影响因子：
--
作者：
Silveira, Vera Maria Freitas da;Horta, Bernardo Lessa
通讯作者：
Horta, Bernardo Lessa
影响因子：
3.6
作者：
de Velasco, Patricia C.;Chicaybam, Gustavo;Tavares-do-Carmo, Maria das Gracas
通讯作者：
Tavares-do-Carmo, Maria das Gracas
影响因子：
3.7
作者：
Borengasser SJ;Kang P;Faske J;Gomez-Acevedo H;Blackburn ML;Badger TM;Shankar K
通讯作者：
Shankar K