Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses.
Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses.
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DOI：
10.3390/v13061084
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发表时间：
2021-06-07
期刊：
影响因子：
--
通讯作者：
Chelico L
中科院分区：
文献类型：
--
作者：
Gaba A;Flath B;Chelico L
病毒从动物宿主到人类的传播导致了几种疾病的出现。通常，这些跨物种传播被宿主限制因子阻断，这些限制因子是可以在特定步骤阻断病毒复制的蛋白质。在天然病毒宿主中，限制因子活性通常被病毒拮抗剂蛋白抑制，但对于来自非天然宿主的限制因子，情况并非如此。然而，由于正在进行的病毒进化，有时病毒拮抗剂可以进化以抑制新宿主中的限制因子，从而实现跨物种传播。在这里，我们通过回顾对APOBEC 3限制因子的研究以及它们如何抑制人类免疫缺陷病毒（HIV）和猿猴免疫缺陷病毒（SIV）来研究这种范式的经典案例。APOBEC 3酶是单链DNA胞苷脱氨酶，如果它们逃避HIV/SIV拮抗剂蛋白Vif，可以通过催化单链病毒（−）DNA上的胞苷转化为前诱变尿苷来诱导前病毒DNA的诱变。Vif通过蛋白酶体途径诱导APOBEC 3降解。SIV在旧大陆猴和原始人之间传播。在这里，我们研究了使这些事件发生的适应性变化以及APOBEC 3-Vif界面对人类HIV的持续影响。
The transmission of viruses from animal hosts into humans have led to the emergence of several diseases. Usually these cross-species transmissions are blocked by host restriction factors, which are proteins that can block virus replication at a specific step. In the natural virus host, the restriction factor activity is usually suppressed by a viral antagonist protein, but this is not the case for restriction factors from an unnatural host. However, due to ongoing viral evolution, sometimes the viral antagonist can evolve to suppress restriction factors in a new host, enabling cross-species transmission. Here we examine the classical case of this paradigm by reviewing research on APOBEC3 restriction factors and how they can suppress human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). APOBEC3 enzymes are single-stranded DNA cytidine deaminases that can induce mutagenesis of proviral DNA by catalyzing the conversion of cytidine to promutagenic uridine on single-stranded viral (−)DNA if they escape the HIV/SIV antagonist protein, Vif. APOBEC3 degradation is induced by Vif through the proteasome pathway. SIV has been transmitted between Old World Monkeys and to hominids. Here we examine the adaptations that enabled such events and the ongoing impact of the APOBEC3-Vif interface on HIV in humans.
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影响因子：
5.2
作者：
Arias JF;Koyama T;Kinomoto M;Tokunaga K
通讯作者：
Tokunaga K
DOI：
10.3390/v13030497
发表时间：
2021-03-17
期刊：
Viruses
影响因子：
--
作者：
Chen XS
通讯作者：
Chen XS
影响因子：
16.6
作者：
Bohn JA;Thummar K;York A;Raymond A;Brown WC;Bieniasz PD;Hatziioannou T;Smith JL
通讯作者：
Smith JL
影响因子：
5.9
作者：
Alqassim EY;Sharma S;Khan ANMNH;Emmons TR;Cortes Gomez E;Alahmari A;Singel KL;Mark J;Davidson BA;Robert McGray AJ;Liu Q;Lichty BD;Moysich KB;Wang J;Odunsi K;Segal BH;Baysal BE
通讯作者：
Baysal BE
影响因子：
4.8
作者：
Aguiar, Renato S.;Lovsin, Nika;Peterlin, B. Matija
通讯作者：
Peterlin, B. Matija