Assessing the accuracy of contact and distance predictions in CASP14.
Assessing the accuracy of contact and distance predictions in CASP14.
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DOI：
10.1002/prot.26248
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发表时间：
2021-12
期刊：
影响因子：
2.9
通讯作者：
Valencia A
中科院分区：
文献类型：
--
作者：
Ruiz-Serra V;Pontes C;Milanetti E;Kryshtafovych A;Lepore R;Valencia A
我们提出的评估结果的分子内残基的接触和距离预测组参与第14轮的CASP实验。接触预测方法的性能与以前的CASP中使用的措施进行了评估，而距离预测进行了评估的基础上，一个新的协议，它考虑到个人的距离对以及整个预测的距离矩阵，使用基于图形的框架。评估结果表明，tFold框架、TripletRes和DeepPotential的预测在这两个类别中是最准确的。关于方法性能的进展，与CASP 13相比，接触预测的评估结果未显示任何明显差异。可以说，这可能是由于CASP14 FM目标比以往任何时候都更具挑战性。
We present the results of the assessment of the intramolecular residue-residue contact and distance predictions from groups participating in the 14th round of the CASP experiment. The performance of contact prediction methods was evaluated with the measures used in previous CASPs, while distance predictions were assessed based on a new protocol, which considers individual distance pairs as well as the whole predicted distance matrix, using a graph-based framework. The results of the evaluation indicate that predictions by the tFold framework, TripletRes and DeepPotential were the most accurate in both categories. With regards to progress in method performance, the results of the assessment in contact prediction did not reveal any discernible difference when compared to CASP13. Arguably, this could be due to CASP14 FM targets being more challenging than ever before.
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