Cognitive dysfunction associated with anti-glutamic acid decarboxylase autoimmunity: a case-control study.
Cognitive dysfunction associated with anti-glutamic acid decarboxylase autoimmunity: a case-control study.
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与抗谷氨酸脱羧酶自身免疫相关的认知功能障碍：病例对照研究。
DOI：
10.1186/1471-2377-13-76
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发表时间：
2013-07-09
期刊：
影响因子：
2.6
通讯作者：
Mori E
中科院分区：
文献类型：
--
作者：
Takagi M;Ishigaki Y;Uno K;Sawada S;Imai J;Kaneko K;Hasegawa Y;Yamada T;Tokita A;Iseki K;Kanno S;Nishio Y;Katagiri H;Mori E
谷氨酸脱羧酶是合成γ-氨基丁酸的限速酶。抗GAD抗体(GADA)与僵人综合征和其他神经系统疾病的进展有关，也与免疫介导的(1型)糖尿病有关。GABA是分布最广泛的神经递质之一，但GADA阳性患者的非运动症状尚不清楚。糖尿病越来越被认为是痴呆症的危险因素；然而，糖尿病和痴呆症之间的关系存在争议。这项研究的目的是评估GADA阳性糖尿病患者的认知功能，并以GADA阴性的2型糖尿病患者为对照。GADA阳性糖尿病患者21例(平均年龄52.5 ± 12.3年，平均病程7.7年 ± 6.6年)和对照组19例(平均年龄53.4 ± 8.9年，平均病程12.5 ± 6.7年)。受试者接受了广泛的神经心理测试和脑核磁共振检查。GADA阳性组神经心理测试得分低于对照组(GADA阴性组)。GADA组有12名受试者(57%)和对照组有4名受试者(21%)表现不佳(p = 0.027)。在人口统计学、糖尿病严重程度、心血管风险、大脑T2高信号、白质体积和灰质体积方面，GADA组和对照组之间没有发现统计学上的差异。我们的研究表明，与同等严重程度的2型糖尿病患者相比，GADA阳性的糖尿病患者认知功能下降的风险更高。研究还表明，在没有其他神经系统并发症的情况下，GADA可能与孤立性认知能力下降有关。
Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA). Anti-GAD antibodies (GADA) are associated with the progression of stiff person syndrome and other neurological diseases, as well as the immune-mediated (type 1) diabetes. GABA is one of the most widely distributed neurotransmitters, but the non-motor symptoms of GADA-positive patients are not well understood. Diabetes is increasingly recognized as a risk factor for dementia; however, the relationship between diabetes and dementia is controversial. The objective of this study was to assess cognitive function in patients with GADA-positive diabetes using subjects with GADA-negative type 2 diabetes as controls. Twenty-one patients with GADA-positive diabetes (mean age 52.5 ± 12.3 years, mean duration 7.7 ± 6.6 years) and 19 control subjects with GADA-negative type 2 diabetes (mean age 53.4 ± 8.9 years, mean duration 12.5 ± 6.7) were included in the study. The subjects underwent extensive neuropsychological testing and brain MRI. The neuropsychological test scores were lower in the GADA-positive group than the control group (GADA-negative). Twelve subjects (57%) in the GADA group and 4 subjects (21%) in the control group had low performances (p = 0.027). No statistically significant differences were found between the GADA and control groups regarding demographics, diabetic severity cardiovascular risks, cerebral T2 hyperintensities, white matter volume and gray matter volume. Our study showed that GADA-positive diabetic patients have an increased risk of cognitive decline compared to patients with type 2 diabetes of comparable diabetic severity. It also showed that GADA may be associated with isolated cognitive decline in the absence of other neurological complications.
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影响因子：
4.4
作者：
Luchsinger, Jose A.
通讯作者：
Luchsinger, Jose A.
影响因子：
64.8
作者：
COBB, SR;BUHL, EH;SOMOGYI, P
通讯作者：
SOMOGYI, P
影响因子：
8.2
作者：
Jacobson, A. M.;Ryan, C. M.;Cleary, P. A.;Waberski, B. H.;Weinger, K.;Musen, G.;Dahms, W.
通讯作者：
Dahms, W.
DOI：
10.3233/jad-2010-091555
发表时间：
2010
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Knopman DS;Roberts R
通讯作者：
Roberts R
影响因子：
8.2
作者：
LANGAN, SJ;DEARY, IJ;FRIER, BM
通讯作者：
FRIER, BM