Malnutrition in early life and adult mental health: evidence from a natural experiment.
Malnutrition in early life and adult mental health: evidence from a natural experiment.
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DOI：
10.1016/j.socscimed.2012.09.051
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发表时间：
2013-11
影响因子：
5.4
通讯作者：
Martorell, Reynaldo
中科院分区：
文献类型：
--
作者：
Huang, Cheng;Phillips, Michael R.;Zhang, Yali;Zhang, Jingxuan;Shi, Qichang;Song, Zhigiang;Ding, Zhijie;Pang, Shutao;Martorell, Reynaldo
作为自然实验，饥荒提供了一个独特的机会来检验生命早期关键时期营养匮乏对健康的影响。我们利用2001年至2005年期间进行的一项大型心理健康流行病学调查中的4，972名1956年至1963年出生的中国人的数据，调查了宫内和产后早期饥饿暴露对成人精神疾病的潜在影响。精神疾病的风险评估与12项一般健康问卷（GHQ-12）和其他八个风险因素，饥荒对成人精神疾病的影响估计的差异中的差异模型。结果表明，与1963年出生的妇女相比，（1959-1961）GHQ得分较高（增加0.95分; CI：0.26，1.65）和精神疾病风险增加（OR= 2.80; CI：1.23，6.39）; 1959年出生的人受影响最大，GHQ得分高1.52分（CI：0.42，2.63），精神疾病的OR为4.99（CI：1.68，14.84）。与1963年出生队列的男性相比，饥荒期间出生的男性的GHQ评分较低（下降0.89分; CI：-1.59，-0.20），精神疾病风险也无显着下降（OR = 0.60; CI：0.26，1.40）。我们推测，早期饥荒暴露的长期后果包括选择最顽强的人和饥荒对幸存者的持久有害影响。在严重饥荒期间，男性胎儿与女性胎儿在子宫内的生物脆弱性更大，自然选择更强，这可能导致男性比女性更强的选择效应，掩盖了饥荒暴露对男性日后患精神疾病风险的有害影响。
As natural experiments, famines provide a unique opportunity to test the health consequences of nutritional deprivation during the critical period of early life. Using data on 4,972 Chinese born between 1956 and 1963 who participated in a large mental health epidemiology survey conducted between 2001 and 2005, we investigated the potential impact of famine exposure in utero and during the early postnatal life on adult mental illness. The risk of mental illness was assessed with the 12-item General Health Questionnaire (GHQ-12) and eight other risk factors, and the famine impact on adult mental illness was estimated by difference-in-difference models. Results show that compared with women born in 1963, women born during the famine years (1959–1961) had higher GHQ scores (increased by 0.95 points; CI: 0.26, 1.65) and increased risk of mental illness (OR= 2.80; CI: 1.23, 6.39); those born in 1959 were the most affected and had GHQ scores 1.52 points higher (CI: 0.42, 2.63) and an OR for mental illness of 4.99 (CI: 1.68, 14.84). Compared to men in the 1963 birth cohort, men born during the famine had lower GHQ scores (decreased by 0.89 points; CI: −1.59, −0.20) and a nonsignificant decrease in the risk of mental illness (OR = 0.60; CI: 0.26, 1.40). We speculate that the long-term consequences of early-life famine exposure include both the selection of the hardiest and the enduring deleterious effects of famine on those who survive. The greater biological vulnerability and stronger natural selection in utero of male versus female fetuses during severe famine may result in a stronger selection effect among men than women, obscuring the deleterious impact of famine exposure on the risk of mental illness in men later in life.
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影响因子：
10.6
作者：
Bale, Tracy L.;Baram, Tallie Z.;Brown, Alan S.;Goldstein, Jill M.;Insel, Thomas R.;McCarthy, Margaret M.;Nemeroff, Charles B.;Reyes, Teresa M.;Simerly, Richard B.;Susser, Ezra S.;Nestler, Eric J.
通讯作者：
Nestler, Eric J.
影响因子：
4.5
作者：
Hankins M
通讯作者：
Hankins M
影响因子：
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作者：
Catalano, Ralph A.;Saxton, Katherine;Anderson, Elizabeth
通讯作者：
Anderson, Elizabeth
影响因子：
168.9
作者：
Black, Robert E.;Victora, Cesar G.;Uauy, Ricardo
通讯作者：
Uauy, Ricardo
影响因子：
17.7
作者：
Brown, AS;van Os, J;Susser, ES
通讯作者：
Susser, ES