Allopregnanolone Is Associated with a Stress-Induced Reduction of Heart Rate Variability in Premenstrual Dysphoric Disorder.
Allopregnanolone Is Associated with a Stress-Induced Reduction of Heart Rate Variability in Premenstrual Dysphoric Disorder.
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DOI：
10.3390/jcm12041553
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发表时间：
2023-02-16
影响因子：
3.9
通讯作者：
Wardle, Margaret
中科院分区：
文献类型：
--
作者：
Hamidovic, Ajna;Davis, John;Soumare, Fatimata;Naveed, Aamina;Ghani, Yaseen;Semiz, Selma;Khalil, Dina;Wardle, Margaret
关键词：
人类的生存和福祉需要对压力做出适当的反应，包括高度协调和有效的神经系统对心率的控制。在应激期间，迷走神经的更大程度的去抑制反映了较差的应激适应能力，这可能与经前焦虑症(PMDD)有关--一种衰弱的情感状态，被认为是以失调的应激处理和对别孕酮的敏感为特征的。在本研究中，17名PMDD妇女和18名健康对照妇女参加了Trier社会应激测试，期间我们使用超高效液相色谱串联质谱仪测量了心率(HF-HRV)和别孕酮的频率。与他们的基线相比，患有经前抑郁症的女性，但不是健康对照组，在压力预期(p≤0.05)和压力(p≤0.01)期间，经历了HF-HRV的降低。他们从应激中恢复的时间明显延迟(p≤0.05)。仅在经前抑郁症组中，基线别孕激素可显著预测心力衰竭心率变异性的绝对峰值变化(p≤)。本研究显示了压力和别孕酮之间的相互作用--这两个因素都分别与PMDD有关--是如何支持PMDD表达的。
Human survival and wellbeing require appropriate responses to stress, including a highly coordinated and efficient nervous system control of the heart rhythm. During stress, a greater disinhibition of the vagal nerve is reflective of poor stress adaptability, which may be relevant in premenstrual dysphoric disorder (PMDD)—a debilitating affective condition thought to be marked by dysregulated stress processing and sensitivity to allopregnanolone. In the present study, women with PMDD (n = 17) and healthy controls (n = 18), who did not take medication, smoke, or consume illicit drugs, and who were free of other psychiatric conditions, participated in the Trier Social Stress Test, during which we measured the high frequency of the heart rate (HF-HRV) and allopregnanolone using ultra-performance liquid chromatography tandem mass spectrometry. Relative to their baseline, women who have PMDD, but not the healthy controls, experienced a reduction in HF-HRV during stress anticipation (p ≤ 0.05) and stress (p ≤ 0.01). Their recovery from stress was significantly delayed (p ≤ 0.05). Absolute peak HF-HRV change from baseline was significantly predicted by baseline allopregnanolone only in the PMDD group (p ≤ 0.01). The present study shows how an interaction between stress and allopregnanolone—which have both been separately implicated in PMDD—underlies PMDD expression.
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影响因子：
2.5
作者：
Brownley, Kimberly A.;Girdler, Susan S.;McLeod, Malcolm N.
通讯作者：
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影响因子：
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Hamidovic A;Soumare F;Naveed A;Davis J;Sun J;Dang N
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Dang N
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通讯作者：
HELLHAMMER, DH
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5
作者：
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通讯作者：
Epperson, C. Neill