Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women's Health Research.
Reduced Dehydroepiandrosterone-Sulfate Levels in the Mid-Luteal Subphase of the Menstrual Cycle: Implications to Women's Health Research.
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DOI：
10.3390/metabo12100941
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发表时间：
2022-10-04
期刊：
影响因子：
4.1
通讯作者：
Dang N
中科院分区：
文献类型：
--
作者：
Hamidovic A;Soumare F;Naveed A;Davis J;Sun J;Dang N
甾体硫酸酯酶（STS）和甾体磺基转移酶（SULT）对脱氢表雄酮硫酸酯酶的调节是许多甾体激素下游形成的重要过程。DHEA-硫酸盐是人体中最丰富的类固醇激素;因此，DHEA-硫酸盐及其水解形式DHEA继续在许多研究中进行评估，因为它们对人类健康很重要。然而，一个与育龄女性相关的基本问题--这两种类固醇激素在月经周期中是否会发生变化--还没有得到解决。我们应用了一种经过验证的多步骤方案，包括将研究数据重新排列和插补到月经周期的早期卵泡、中晚期卵泡、排卵期以及早期、中期和晚期黄体亚相，并使用超高效液相色谱串联质谱法分析了硫酸脱氢表雄酮和脱氢表雄酮血清浓度。硫酸脱氢表雄酮水平在黄体早期开始下降，在黄体中期显著下降，并在黄体后期恢复到基础水平。然而，DHEA在月经周期中没有变化。本研究深入绘制了整个月经周期中DHEA和DHEA-硫酸盐的轨迹，表明在黄体中期DHEA-硫酸盐显著减少。这些发现与研究DHEA-硫酸盐水平与各种疾病状态之间关系的活跃领域有关。
The regulation of DHEA-sulfate by steroid sulfotransferase (SULT) and steryl-sulfatase (STS) enzymes is a vital process for the downstream formation of many steroid hormones. DHEA-sulfate is the most abundant steroid hormone in the human body; thus, DHEA-sulfate and its hydrolyzed form, DHEA, continue to be evaluated in numerous studies, given their importance to human health. Yet, a basic question of relevance to the reproductive-age female population—whether the two steroid hormones vary across the menstrual cycle—has not been addressed. We applied a validated, multi-step protocol, involving realignment and imputation of study data to early follicular, mid-late follicular, periovulatory, and early, mid-, and late luteal subphases of the menstrual cycle, and analyzed DHEA-sulfate and DHEA serum concentrations using ultraperformance liquid chromatography tandem mass spectrometry. DHEA-sulfate levels started to decrease in the early luteal, significantly dropped in the mid-luteal, and returned to basal levels by the late luteal subphase. DHEA, however, did not vary across the menstrual cycle. The present study deep-mapped trajectories of DHEA and DHEA-sulfate across the entire menstrual cycle, demonstrating a significant decrease in DHEA-sulfate in the mid-luteal subphase. These findings are relevant to the active area of research examining associations between DHEA-sulfate levels and various disease states.
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影响因子：
7.6
作者：
Genud, Rotem;Merenlender, Avia;Yadid, Gal
通讯作者：
Yadid, Gal
影响因子：
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Howards, Penelope P.;Schisterman, Enrique F.;Hovey, Kathleen M.
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通讯作者：
Falany, CN
影响因子：
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Heuser, I;Deuschle, M;Weber, B
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Weber, B