Lean Principles to Improve Quality in High-Throughput COVID-19 Testing Using SwabSeq: A Barcoded Sequencing-Based Testing Platform.
Lean Principles to Improve Quality in High-Throughput COVID-19 Testing Using SwabSeq: A Barcoded Sequencing-Based Testing Platform.
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使用SwabSeq：基于条形码测序的测试平台提高高重复性COVID-19测试质量的精益原则。
DOI：
10.1093/labmed/lmab069
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发表时间：
2022-01-06
影响因子：
1.3
通讯作者：
Arboleda VA
中科院分区：
文献类型：
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作者：
Jones J;Saul R;Sathe L;Xie J;Marquette D;Arboleda VA
描述和量化质量控制（QC）指标对提高高复杂性、临床实验室改进修正案认证实验室检测效率的影响，该实验室使用基于扩增子的下一代测序进行SARS-CoV-2的临床检测。为了在没有全自动化平台的情况下实现每天数千个样本的快速可扩展性，我们开发了内部QC方法，以确保高精度测试。我们实施了程序，通过将精益六西格玛模型应用于我们基于测序的COVID-19检测来提高效率。精益六西格玛模式的应用通过减少错误提高了实验室效率，从而可以用最少的人员配备来满足更大的检测量。此外，这些改进还缩短了周转时间。精益六西格玛模型的执行通过减少关键的测试错误提高了实验室的效率，并使实验室为将来每天50，000次测试做好了准备。
To describe and quantify the effect of quality control (QC) metrics to increase testing efficiency in a high-complexity, Clinical Laboratory Improvement Amendments–certified laboratory that uses amplicon-based, next generation sequencing for the clinical detection of SARS-CoV-2. To enable rapid scalability to several thousands of specimens per day without fully automated platforms, we developed internal QC methods to ensure high-accuracy testing. We implemented procedures to increase efficiency by applying the Lean Six Sigma model into our sequencing-based COVID-19 detection. The application of the Lean Six Sigma model increased laboratory efficiency by reducing errors, allowing for a higher testing volume to be met with minimal staffing. Furthermore, these improvements resulted in an improved turnaround time. Lean Six Sigma model execution has increased laboratory efficiency by decreasing critical testing errors and has prepared the laboratory for future scaling up to 50,000 tests per day.
影响因子：
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作者：
Coakley, Meghan;Hurt, Darrell E.
通讯作者：
Hurt, Darrell E.
影响因子：
28.1
作者：
通讯作者：
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影响因子：
2.6
作者：
Schweikhart, Sharon A.;Dembe, Allard E.
通讯作者：
Dembe, Allard E.