Similarities in mode and sites of action of sarafotoxins and endothelins.
Similarities in mode and sites of action of sarafotoxins and endothelins.
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萨拉福毒素和内皮素的作用方式和位点相似。
DOI：
10.1016/0165-6147(89)90261-7
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发表时间：
1989
影响因子：
13.8
通讯作者：
M. Sokolovsky
中科院分区：
文献类型：
--
作者：
Y. Kloog;M. Sokolovsky
一个新的肽受体通讯途径连接到磷酸肌醇第二信使系统和Ca 2+信号转导机制最近已被发现的蛇毒毒素1的使用，并通过发现哺乳动物血管收缩肽内皮素2。血管收缩心脏毒性肽，sarafotoxins（SRTXs），其来源于naO_ve以色列蛇Eingadensis 3，4，以高亲和力结合到大鼠心房和脑中的新的膜结合受体，其偶联到磷酸肌醇（PI）系统1，s。6. SRTXs（SRTX-a、SRTX-b和SRTX-c）1“3和哺乳动物内皮素2”7”8（现称为ET-1、ET-2和ET-3，见参考文献9）之间异常高的序列同源性（图1）表明，后者的肽可能是“SRTX受体”的内源性配体。这一概念得到了直接结合1 '11和PI水解数据的支持。
A new peptide-receptor communications pathway linked to the phosphoinositide second messenger system and to the Ca 2+ signal-transduction mechanism has recently been uncovered by the use of snake venom toxins 1, and by the discovery of the mammalian vasoconstrictor peptide endothelin 2. The vasoconstrictorcardiotoxic peptides, the sarafotoxins (SRTXs), which are derived from the naO_'ve Israeli snake Atractaspis eingadensis 3, 4, bind with high affinity to a novel membranebound receptor in rat atrium and brain, which is coupled to the phosphoinositide (PI) system 1, s. 6. The unusually high degree of sequence homology (Fig. 1) between the SRTXs (SRTX-a, SRTX-b and SRTX-c) 1'3 and the mammalian endothelins 2" 7" 8 (now called ET-1, ET-2 and ET-3, see Ref. 9), suggests that the latter peptides might be the endogenous ligands for the'SRTX receptors'. This notion is supported by direct binding 1'11 and PI hydrolysis data.
内皮素对清醒大鼠局部血流动力学的影响。
影响因子：
5
作者：
Han,SP;Trapani,AJ;Fok,KF;Westfall,TC;Knuepfer,MM
通讯作者：
Knuepfer,MM
内皮素对体内全身和肾血管床的影响。
影响因子：
5
作者：
Lippton,H;Goff,J;Hyman,A
通讯作者：
Hyman,A