Making teeth to order: conserved genes reveal an ancient molecular pattern in paddlefish (Actinopterygii).
Making teeth to order: conserved genes reveal an ancient molecular pattern in paddlefish (Actinopterygii).
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DOI：
10.1098/rspb.2014.2700
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发表时间：
2015-04-22
期刊：
影响因子：
--
通讯作者：
Fraser GJ
中科院分区：
文献类型：
--
作者：
Smith MM;Johanson Z;Butts T;Ericsson R;Modrell M;Tulenko FJ;Davis MC;Fraser GJ
辐鳍鱼（Actinopteri）是当今占主导地位的脊椎动物群（超过30 000种，主要是硬骨鱼），具有巨大的形态多样性，包括它们的齿系。牙齿形态的变化如何演变是最好的解决，通过考虑一系列的类群，在actinopterygian spectogeny;在这里，我们研究齿的Polyodon spathula（美国白鲟），分配到基础组鲟形目。虽然牙齿在年轻的多齿龙个体中存在并起作用，但它们在成年人中完全没有。我们目前的理解发育基因在牙列主要限于硬骨鱼;我们表明，SHH和BMP 4，作为高度保守的上皮和间充质基因的颚口类牙齿发育，同样表达在Polyodon牙齿位点，从而延长这种保守的发展模式内的Actinoportii。这些基因映射的时空牙齿启动在多齿龙幼虫，并提供新的数据，在口腔和咽部的牙齿网站。shh细胞强度的变化映射了牙齿形态发生的时间，揭示了第二个牙源性波作为牙列内的交替位点，这种牙齿模式也存在于更多的衍生放线菌中。在Polyodon每个牙齿领域的发展时间如下梯度，从喙尾和腹背，重复在随后的牙齿损失。过渡性多齿龙的齿系是通过停止牙齿的增加和脱落而改变的。因此，Polyodon代表了一个基础的Actinopterygian模型的发展新奇的演变：最初的保护，其次是牙齿的损失，适应成人营养修改过滤器喂养。
Ray-finned fishes (Actinopterygii) are the dominant vertebrate group today (+30 000 species, predominantly teleosts), with great morphological diversity, including their dentitions. How dental morphological variation evolved is best addressed by considering a range of taxa across actinopterygian phylogeny; here we examine the dentition of Polyodon spathula (American paddlefish), assigned to the basal group Acipenseriformes. Although teeth are present and functional in young individuals of Polyodon, they are completely absent in adults. Our current understanding of developmental genes operating in the dentition is primarily restricted to teleosts; we show that shh and bmp4, as highly conserved epithelial and mesenchymal genes for gnathostome tooth development, are similarly expressed at Polyodon tooth loci, thus extending this conserved developmental pattern within the Actinopterygii. These genes map spatio-temporal tooth initiation in Polyodon larvae and provide new data in both oral and pharyngeal tooth sites. Variation in cellular intensity of shh maps timing of tooth morphogenesis, revealing a second odontogenic wave as alternate sites within tooth rows, a dental pattern also present in more derived actinopterygians. Developmental timing for each tooth field in Polyodon follows a gradient, from rostral to caudal and ventral to dorsal, repeated during subsequent loss of teeth. The transitory Polyodon dentition is modified by cessation of tooth addition and loss. As such, Polyodon represents a basal actinopterygian model for the evolution of developmental novelty: initial conservation, followed by tooth loss, accommodating the adult trophic modification to filter-feeding.
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影响因子：
2.6
作者：
Davis, Marcus C.
通讯作者：
Davis, Marcus C.
基础射线鳍鱼神经源性基板发育的分子分析。
影响因子：
1.5
作者：
Modrell, Melinda S.;Buckley, David;Baker, Clare V. H.
通讯作者：
Baker, Clare V. H.
影响因子：
2.2
作者：
Clemen, G;Bartsch, P;Wacker, K
通讯作者：
Wacker, K
DOI：
10.1098/rspb.2008.1364
发表时间：
2009-02-22
影响因子：
4.7
作者：
Smith, Moya M.;Okabe, Masataka;Joss, Jean
通讯作者：
Joss, Jean
DOI：
10.1073/pnas.1119635109
发表时间：
2012-05-22
影响因子：
11.1
作者：
Fraser, Gareth J.;Britz, Ralf;Smith, Moya M.
通讯作者：
Smith, Moya M.