Magic angle effect on diffusion tensor imaging in ligament and brain.
Magic angle effect on diffusion tensor imaging in ligament and brain.
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DOI：
10.1016/j.mri.2022.06.008
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发表时间：
2022-10
影响因子：
2.5
通讯作者：
Spritzer, Charles E.
中科院分区：
文献类型：
--
作者：
Wang, Nian;Wen, Qiuting;Maharjan, Surendra;Mirando, Anthony J.;Qi, Yi;Hilton, Matthew J.;Spritzer, Charles E.
目的探讨魔角对大鼠韧带和小鼠脑弥散张量成像（DTI）测量的影响。采用改进的三维扩散加权自旋回波脉冲序列，各向同性空间分辨率为45 μm，在9.4T下扫描3只大鼠膝关节和3只小鼠大脑。大鼠膝关节b值为1000 s/mm2，小鼠脑b值为4000 s/mm2。采用DTI模型研究了不同方向上相对于主磁场的定量指标。用偏振光显微镜（PLM）成像证实了韧带的胶原纤维结构。韧带的信号强度、信噪比（SNR）和DTI指标与模拟和实际MRI扫描中胶原纤维相对于主磁场的方向密切相关。分数各向异性（FA）的变化约为32%，平均扩散率（MD）的变化约为11%。不同信噪比（~10.0 ~ 86.0）下的数值模拟进一步验证了上述结果。与韧带相比，DTI指标在小鼠大脑中显示出很少的方向依赖性。在高度有序的富胶原组织中，魔角效应在DTI测量中起重要作用，而MD对取向的依赖性小于FA。
To evaluate the magic angle effect on diffusion tensor imaging (DTI) measurements in rat ligaments and mouse brains. Three rat knee joints and three mouse brains were scanned at 9.4T using a modified 3D diffusion-weighted spin echo pulse sequence with the isotropic spatial resolution of 45 μm. The b value was 1000 s/mm2 for rat knee and 4000 s/mm2 for mouse brain. DTI model was used to investigate the quantitative metrics at different orientations with respect to the main magnetic field. The collagen fiber structure of the ligament was validated with polarized light microscopy (PLM) imaging. The signal intensity, signal-to-noise ratio (SNR), and DTI metrics in the ligament were strongly dependent on the collagen fiber orientation with respect to the main magnetic field from both simulation and actual MRI scans. The variation of fractional anisotropy (FA) was about ~ 32%, and the variation of mean diffusivity (MD) was ~ 11%. These findings were further validated with the numerical simulation at different SNRs (~10.0 to 86.0). Compared to the ligament, the DTI metrics showed little orientation dependence in mouse brains. Magic angle effect plays an important role in DTI measurements in the highly ordered collagen-rich tissues, while MD showed less orientation dependence than FA.
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影响因子：
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作者：
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