The oral administration of low-dose antigen induces activation followed by tolerization, while high-dose antigen induces tolerance without activation.
The oral administration of low-dose antigen induces activation followed by tolerization, while high-dose antigen induces tolerance without activation.
复制标题
口服低剂量抗原诱导活化，随后产生耐受，而高剂量抗原则诱导耐受但不活化。
DOI：
--
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
S. Kaminogawa
中科院分区：
文献类型：
--
作者：
Tadashi Yoshida;S. Hachimura;S. Kaminogawa
研究了不同剂量牛α s1-酪蛋白口服给药诱导的全身免疫应答和耐受，重点是细胞因子应答。来自喂食低剂量抗原的小鼠的脾细胞分泌干扰素-γ和白细胞介素-2以响应体外抗原刺激，表明诱导了Th 1型应答。在这些小鼠中，随后免疫和用抗原加强后的Th 1应答减弱。在喂食高剂量抗原的小鼠的情况下，Th 1细胞因子的分泌是最小的，但随后的免疫和用抗原加强后的全身反应被强烈抑制。在任何剂量下均未观察到活性抑制。结果表明，在这个系统中，低剂量喂养诱导活化的Th 1细胞随后耐受，而高剂量喂养诱导深刻的耐受性没有事先激活。我们的研究结果对口服耐受性在变态反应和自身免疫性疾病中的临床应用具有指导意义。
The systemic immune response and tolerance induced by oral administration of various doses of bovine alpha s1-casein were examined, focusing on cytokine responses in this study. Spleen cells from mice fed low doses of antigen secreted interferon-gamma and interleukin-2 in response to in vitro antigen stimulation, indicating that a Th1-type response was induced. In these mice, the Th1 responses after subsequent immunization and boosting with the antigen were diminished. In the case of mice fed high doses of the antigen, secretion of Th1 cytokines was minimal, but systemic responses after subsequent immunization and boosting with the antigen were strongly inhibited. Active suppression was not observed at any dose. The results indicate that, in this system, low-dose feeding induced activation of Th1 cells followed by tolerization, while high-dose feeding induced profound tolerance without prior activation. Our results have implications for clinical application of oral tolerance to allergy and autoimmune disease.
登录
查看更多内容
影响因子：
56.9
作者：
CHEN, YH;KUCHROO, VK;WEINER, HL
通讯作者：
WEINER, HL
DOI：
10.1073/pnas.91.14.6688
发表时间：
1994-07-05
影响因子：
11.1
作者：
FRIEDMAN, A;WEINER, HL
通讯作者：
WEINER, HL
影响因子：
56.9
作者：
TRENTHAM, DE;DYNESIUSTRENTHAM, RA;WEINER, HL
通讯作者：
WEINER, HL
DOI：
10.1073/pnas.89.1.421
发表时间：
1992-01-01
影响因子：
11.1
作者：
MILLER, A;LIDER, O;WEINER, HL
通讯作者：
WEINER, HL
通过口服免疫选择性诱导小鼠派尔氏淋巴集结中的 Th2 细胞。
影响因子：
4.4
作者：
Xu-Amano,J;Aicher,WK;Taguchi,T;Kiyono,H;McGhee,JR
通讯作者：
McGhee,JR