Optimizing PiB-PET SUVR change-over-time measurement by a large-scale analysis of longitudinal reliability, plausibility, separability, and correlation with MMSE.
Optimizing PiB-PET SUVR change-over-time measurement by a large-scale analysis of longitudinal reliability, plausibility, separability, and correlation with MMSE.
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DOI：
10.1016/j.neuroimage.2016.08.056
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发表时间：
2017-01-01
期刊：
影响因子：
5.7
通讯作者：
Jack CR Jr
中科院分区：
文献类型：
--
作者：
Schwarz CG;Senjem ML;Gunter JL;Tosakulwong N;Weigand SD;Kemp BJ;Spychalla AJ;Vemuri P;Petersen RC;Lowe VJ;Jack CR Jr
从正电子发射断层扫描（PET）图像定量测量β-淀粉样蛋白负荷的变化在阿尔茨海默病的临床试验和纵向观察研究中起着关键作用。这些测量受到实施之间的方法差异的强烈影响，包括参考区域的选择和部分体积校正的使用，但是对于最佳方法缺乏共识。以前的工作已经检查了不同标准下的一些相关变量，但它们之间的相互作用，防止选择一种方法，通过联合荟萃分析。在这项工作中，我们提出了一个彻底的比较方法来衡量随着时间的推移，使用匹兹堡化合物B（PiB）PET成像β-淀粉样蛋白的变化。我们比较了1,024种不同的自动化软件管道实现，根据129名受试者在三个时间点纵向轨迹上计算的四个质量指标进行了不同的方法选择：可靠性（平直度/方差）;可弯曲性（无负斜率）;能够根据基线值预测蓄电池/非蓄电池状态;以及β-淀粉样蛋白变化与简易精神状态检查（MMSE）评分变化之间的相关性。从这个分析中，我们表明，从PiB的β-淀粉样蛋白的最佳纵向测量应该使用一个参考区域，其中包括在幕上白色物质和那些在整个小脑的体素的组合，使用两个类的部分体积校正在每个主题的相应的解剖MR图像的体素空间测量。
Quantitative measurements of change in β-amyloid load from Positron Emission Tomography (PET) images play a critical role in clinical trials and longitudinal observational studies of Alzheimer’s disease. These measurements are strongly affected by methodological differences between implementations, including choice of reference region and use of partial volume correction, but there is a lack of consensus for an optimal method. Previous works have examined some relevant variables under varying criteria, but interactions between them prevent choosing a method via combined meta-analysis. In this work, we present a thorough comparison of methods to measure change in β-amyloid over time using Pittsburgh Compound B (PiB) PET imaging. We compare 1,024 different automated software pipeline implementations with varying methodological choices according to four quality metrics calculated over three-timepoint longitudinal trajectories of 129 subjects: reliability (straightness/variance); plausibility (lack of negative slopes); ability to predict accumulator/non-accumulator status from baseline value; and correlation between change in β-amyloid and change in Mini Mental State Exam (MMSE) scores. From this analysis, we show that an optimal longitudinal measure of β-amyloid from PiB should use a reference region that includes a combination of voxels in the supratentorial white matter and those in the whole cerebellum, measured using two-class partial volume correction in the voxel space of each subject’s corresponding anatomical MR image.
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