Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling.
Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling.
复制标题
协调基因表达和轴突组装以控制轴突生长：GSK3信号的潜在作用。
DOI：
10.3389/fnmol.2012.00003
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发表时间：
2012
影响因子：
4.8
通讯作者：
Zhou FQ
中科院分区：
文献类型：
--
作者：
Liu CM;Hur EM;Zhou FQ
轴突生长需要协调调节神经元索马中的基因表达、轴突中的局部蛋白质翻译、合成原料沿着轴突的顺行运输以及神经生长锥中细胞骨架和膜的组装。糖原合成酶激酶3（GSK3）信号通路在轴突生长过程中对轴突运输和细胞骨架组装起着重要的调节作用。GSK3信号也已知通过控制许多转录因子的功能来调节基因表达，这表明GSK3可能是支持轴突生长的基因转录的重要调节因子。我们审查信号通路，控制局部轴突组装在生长锥和基因表达的索马在发育或再生轴突生长和讨论的潜在参与这些过程中的GSK3信号，特别关注如何GSK3信号调节轴突生长相关的转录因子的功能。
Axon growth requires the coordinated regulation of gene expression in the neuronal soma, local protein translation in the axon, anterograde transport of synthesized raw materials along the axon, and assembly of cytoskeleton and membranes in the nerve growth cone. Glycogen synthase kinase 3 (GSK3) signaling has recently been shown to play key roles in the regulation of axonal transport and cytoskeletal assembly during axon growth. GSK3 signaling is also known to regulate gene expression via controlling the functions of many transcription factors, suggesting that GSK3 may be an important regulator of gene transcription supporting axon growth. We review signaling pathways that control local axon assembly at the growth cone and gene expression in the soma during developmental or regenerative axon growth and discuss the potential involvement of GSK3 signaling in these processes, with a particular focus on how GSK3 signaling modulates the function of axon growth-associated transcription factors.
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