Developmental trajectory of episodic-like memory in rats.
Developmental trajectory of episodic-like memory in rats.
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DOI：
10.3389/fnbeh.2022.969871
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发表时间：
2022
影响因子：
3
通讯作者：
Wood ER
中科院分区：
文献类型：
--
作者：
Asiminas A;Lyon SA;Langston RF;Wood ER
情景记忆的形成需要将多种关联与连贯的情景表征结合起来，并具有丰富的时间、地点和上下文信息的细节。在出生后发育过程中，回忆情景记忆的能力比其他类型的记忆（例如物体识别）出现得晚。然而，大鼠从断奶到成年的情景记忆的精确发展轨迹尚未确定。自发物体探索任务不需要训练，并且允许对受试者进行重复测试，前提是每次试验都使用新颖的物体。因此，这些任务非常适合研究情景记忆及其组成部分（例如物体、空间和情境记忆）的个体发育。在本研究中，我们在两天内使用了四个自发的短期物体探索任务：物体（OR）、物体-上下文（OCR）、物体-地点（OPR）和物体-地点-上下文（OPCR）识别来表征三种常用近交系大鼠（Lister Hooded、Long Evans Hooded和Sprague Dawley）的情景样记忆及其组成部分的个体发育。在从 3-4 周龄开始的纵向研究中，我们观察到对物体的短期记忆在我们测试的最早时间点就已经存在，表明它是在生命第三周结束之前建立的（与其他几份报告一致）。物体-情境记忆在出生后第五周形成，而物体-地点记忆和情景式物体-地点-情境记忆在出生后第七周左右形成。为了控制先前经验对联想记忆发展的影响，我们使用横截面协议确认了这些发展轨迹。我们的工作为大鼠识别记忆的不同发展轨迹提供了强有力的证据，这取决于关联的内容和/或复杂性，并强调自发对象探索任务在评估具有高时间分辨率的记忆系统的个体发育方面的效用。
Episodic memory formation requires the binding of multiple associations to a coherent episodic representation, with rich detail of times, places, and contextual information. During postnatal development, the ability to recall episodic memories emerges later than other types of memory such as object recognition. However, the precise developmental trajectory of episodic memory, from weaning to adulthood has not yet been established in rats. Spontaneous object exploration tasks do not require training, and allow repeated testing of subjects, provided novel objects are used on each trial. Therefore, these tasks are ideally suited for the study of the ontogeny of episodic memory and its constituents (e.g., object, spatial, and contextual memory). In the present study, we used four spontaneous short-term object exploration tasks over two days: object (OR), object-context (OCR), object-place (OPR), and object-place-context (OPCR) recognition to characterise the ontogeny of episodic-like memory and its components in three commonly used outbred rat strains (Lister Hooded, Long Evans Hooded, and Sprague Dawley). In longitudinal studies starting at 3–4 weeks of age, we observed that short term memory for objects was already present at the earliest time point we tested, indicating that it is established before the end of the third week of life (consistent with several other reports). Object-context memory developed during the fifth week of life, while both object-in-place and the episodic-like object-place-context memory developed around the seventh postnatal week. To control for the effects of previous experience in the development of associative memory, we confirmed these developmental trajectories using a cross-sectional protocol. Our work provides robust evidence for different developmental trajectories of recognition memory in rats depending on the content and/or complexity of the associations and emphasises the utility of spontaneous object exploration tasks to assess the ontogeny of memory systems with high temporal resolution.
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DOI：
10.1523/jneurosci.0925-21.2021
发表时间：
2021-10-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Berg EL;Jami SA;Petkova SP;Berz A;Fenton TA;Lerch JP;Segal DJ;Gray JA;Ellegood J;Wöhr M;Silverman JL
通讯作者：
Silverman JL
影响因子：
8.2
作者：
Hunt, Pamela S.;Burk, Joshua A.;Barnet, Robert C.
通讯作者：
Barnet, Robert C.
影响因子：
2.7
作者：
Dix, SL;Aggleton, JP
通讯作者：
Aggleton, JP
影响因子：
2
作者：
Balderas, Israela;Rodriguez-Ortiz, Carlos J.;Bermudez-Rattoni, Federico
通讯作者：
Bermudez-Rattoni, Federico
影响因子：
2.5
作者：
Clemens, L. E.;Jansson, E. K. H.;Nguyen, H. P.
通讯作者：
Nguyen, H. P.