Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human natural killer gene complex.
Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human natural killer gene complex.
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DOI：
10.3389/fimmu.2013.00362
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发表时间：
2013-11-07
影响因子：
7.3
通讯作者：
Steinle A
中科院分区：
文献类型：
--
作者：
Bartel Y;Bauer B;Steinle A
自然杀伤（NK）细胞的功能反应，包括根除“有害”细胞和调节免疫反应是由多种激活和抑制NK受体调节。白细胞受体复合物（LRC）编码免疫球蛋白超家族的NK受体，而C型凝集素样NK受体的基因聚集在哺乳动物自然杀伤基因复合物（NKC）中。除了深入研究的C型凝集素样受体NKG 2D、CD 94/NKG 2x和鼠Ly 49亚家族成员外，NKC还编码较少表征的NKRP 1亚家族的NK受体。原型小鼠NKRP 1受体是Nkrp 1c（也称为NK1.1），而NKRP 1亚家族的人类成员是NKRP 1A，NKp 80和NKp 65。后者不是小鼠NKRP 1受体的直接同源物，但共享不同的亚家族特异性特征，将它们分类为NKRP 1亚家族的成员。人NKPR 1受体的配体同样是属于CLEC 2亚家族的C型凝集素样糖蛋白（即，LLT 1、AICL和KACL），并在NKC中编码，与其各自的受体紧密遗传连锁。类似地，小鼠NKRP 1亚家族的某些成员与基因偶联的CLEC 2糖蛋白相互作用，而这种有趣的紧密遗传连锁的原因仍然未知。最近的研究为NKRP 1受体及其配体的表达、相互作用和信号传导提供了新的独特见解，从而大大促进了我们对其功能和生物学的理解。在这里，我们回顾了我们目前对NKRP 1受体及其遗传相关的CLEC 2配体的了解，重点是人类受体/配体对NKRP 1A-LLT 1、NKp 80-AICL和NKp 65-KACL。
Functional responses of natural killer (NK) cells including eradication of “harmful” cells and modulation of immune responses are regulated by a broad variety of activating and inhibitory NK receptors. Whereas the leukocyte receptor complex (LRC) encodes for NK receptors of the immunoglobulin superfamily, genes of C-type lectin-like NK receptors are clustered in the mammalian natural killer gene complex (NKC). Besides the thoroughly studied C-type lectin-like receptors NKG2D, CD94/NKG2x, and members of the murine Ly49 subfamily, the NKC also encodes for NK receptors of the less characterized NKRP1 subfamily. The prototypic mouse NKRP1 receptor is Nkrp1c (also known as NK1.1), while human members of the NKRP1 subfamily are NKRP1A, NKp80, and NKp65. The latter are not straight homologs of mouse NKRP1 receptors, but share distinct subfamily-specific traits classifying them as members of the NKRP1 subfamily. Ligands of the human NKPR1 receptors are likewise C-type lectin-like glycoproteins belonging to the CLEC2 subfamily (i.e., LLT1, AICL, and KACL), and are encoded in the NKC in tight genetic linkage to their respective receptors. Similarly, certain members of the mouse NKRP1 subfamily interact with genetically coupled CLEC2 glycoproteins, while the reasons for this intriguing tight genetic linkage remain unknown. Recent studies provided new and unique insights into the expression, interaction, and signaling of NKRP1 receptors and their ligands, thereby substantially advancing our understanding of their function and biology. Here, we review our current knowledge on NKRP1 receptors and their genetically linked CLEC2 ligands with an emphasis on the human receptor/ligand pairs NKRP1A-LLT1, NKp80-AICL, and NKp65-KACL.
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影响因子：
4.4
作者：
Dalbeth, N;Gundle, R;Callan, MFC
通讯作者：
Callan, MFC
DOI：
10.1073/pnas.0802736105
发表时间：
2008-05-06
影响因子：
11.1
作者：
Kaiser, Brett K.;Pizarro, Juan Carlos;Strong, Roland K.
通讯作者：
Strong, Roland K.
影响因子：
56.9
作者：
Bauer, S;Groh, V;Spies, T
通讯作者：
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影响因子：
4.4
作者：
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通讯作者：
Braud, VM
影响因子：
20.3
作者：
Hughes CE;Pollitt AY;Mori J;Eble JA;Tomlinson MG;Hartwig JH;O'Callaghan CA;Fütterer K;Watson SP
通讯作者：
Watson SP