Relation between obesity and bone mineral density and vertebral fractures in Korean postmenopausal women.
Relation between obesity and bone mineral density and vertebral fractures in Korean postmenopausal women.
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DOI：
10.3349/ymj.2010.51.6.857
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发表时间：
2010-11
影响因子：
2.4
通讯作者：
Lee DC
中科院分区：
文献类型：
--
作者：
Kim KC;Shin DH;Lee SY;Im JA;Lee DC
肥胖可以预防骨质疏松症的传统观念受到了质疑。最近的流行病学研究表明，身体脂肪本身可能是骨质疏松症和骨折的危险因素。越来越多的证据表明，代谢综合征和代谢综合征的各个组成部分，如高血压、甘油三酯升高和高密度脂蛋白胆固醇降低也是低骨密度的危险因素。采用横断面研究设计，我们评估了肥胖或代谢综合征与骨密度（BMD）或椎体骨折之间的关系。从韩国首尔的妇科医院招募了总计907名绝经后健康女性受试者，年龄为60-79岁。测量BMD、椎骨骨折、骨标志物和身体成分，包括体重、体重指数（BMI）、体脂百分比和腰围。校正年龄、吸烟状况、饮酒量、总钙摄入量和总能量摄入量后，腰围与所有部位的BMD呈负相关（腰椎BMD p = 0.037，股骨BMD所有部位p < 0.001），而体重与所有部位的BMD仍呈正相关（p < 0.001）。骨折组的体脂百分比和腰围远高于非骨折组（分别为p = 0.0383，0.082）。血清葡萄糖水平与腰椎BMD（p = 0.016）、股骨颈BMD（p = 0.0335）和股骨转子BMD（p = 0.0082）呈正相关。血清高密度脂蛋白胆固醇（HDLC）与股骨转子BMD呈正相关（p = 0.0366），对照组低于骨折组（p = 0.011）。与体重对骨密度的影响相反，高百分比的体脂和腰围与低BMD和椎骨骨折有关。代谢综合征的某些成分与BMD和椎骨骨折有关。
The traditional belief that obesity is protective against osteoporosis has been questioned. Recent epidemiologic studies show that body fat itself may be a risk factor for osteoporosis and bone fractures. Accumulating evidence suggests that metabolic syndrome and the individual components of metabolic syndrome such as hypertension, increased triglycerides, and reduced high-density lipoprotein cholesterol are also risk factors for low bone mineral density. Using a cross sectional study design, we evaluated the associations between obesity or metabolic syndrome and bone mineral density (BMD) or vertebral fracture. A total of 907 postmenopausal healthy female subjects, aged 60-79 years, were recruited from woman hospitals in Seoul, South Korea. BMD, vetebral fracture, bone markers, and body composition including body weight, body mass index (BMI), percentage body fat, and waist circumference were measured. After adjusting for age, smoking status, alcohol consumption, total calcium intake, and total energy intake, waist circumference was negatively related to BMD of all sites (lumbar BMD p = 0.037, all sites of femur BMD p < 0.001) whereas body weight was still positively related to BMD of all sites (p < 0.001). Percentage body fat and waist circumference were much higher in the fracture group than the non-fracture group (p = 0.0383, 0.082 respectively). Serum glucose levels were postively correlated to lumbar BMD (p = 0.016), femoral neck BMD (p = 0.0335), and femoral trochanter BMD (p = 0.0082). Serum high density lipoprotein cholesterol (HDLC) was positively related to femoral trochanter BMD (p = 0.0366) and was lower in the control group than the fracture group (p = 0.011). In contrast to the effect favorable body weight on bone mineral density, high percentage body fat and waist circumference are related to low BMD and a vertebral fracture. Some components of metabolic syndrome were related to BMD and a vertebral fracture.
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DOI：
10.1088/0143-0815/10/1/006
发表时间：
1989-02-01
期刊：
CLINICAL PHYSICS AND PHYSIOLOGICAL MEASUREMENT
影响因子：
--
作者：
FARRELL, TJ;WEBBER, CE
通讯作者：
WEBBER, CE
DOI：
10.1111/j.0197-3118.2006.05457.x
发表时间：
2006-01-01
期刊：
Journal of the cardiometabolic syndrome
影响因子：
--
作者：
McFarlane, Samy I
通讯作者：
McFarlane, Samy I
脂质谱，肥胖和骨矿物质密度：赫特福德郡队列研究。
影响因子：
13.3
作者：
Dennison, E M;Syddall, H E;Aihie Sayer, A;Martin, H J;Cooper, C
通讯作者：
Cooper, C
影响因子：
5.8
作者：
Janicka, Agnieszka;Wren, Tishya A. L.;Gilsanz, Vicente
通讯作者：
Gilsanz, Vicente
影响因子：
3.7
作者：
Luo, XH;Guo, LJ;Liao, EY
通讯作者：
Liao, EY